大光斑低能量调Q开关Nd：YAG激光治疗黄褐斑的疗效  

Efficacy of great spot low energy Q switch Nd ： YAG laser on melasma

作　　者：潘虹 宋为民[2] 沈静[2] 郑涵[2] 周梦云[2] 胡玲玲[2] 郭波[2] 许爱娥[2] 

机构地区：[1]武汉市第三医院整形外科,430060 [2]杭州市第三人民医院激光美容中心

出　　处：《中华医学美学美容杂志》2011年第5期355-358,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的探讨大光斑低能挝调Q开关Nd：YAG1064nm激光治疗黄褐斑的疗效和安全性。方法对45例黄褐斑患者，使用大光斑低能量调Q开关Nd：YAG1064nm激光治疗，每周1次．每例患行治疗11～20次，分别于治疗前、治疗5周、10周以及治疗完成时，进行患者自评疗效、医师评价以及皮肤多功能测试仪检测皮肤黑素指数和经皮水分丢失评价。结果黄褐斑皮损区激光治疗5周、10周、完成时黑素指数较治疗前均有显著性减少，正常皮肤区治疗前后无差异；治疗5次、10次和完成时经皮水分较治疗前均有显著性增高，治疗后患者的皮肤光滑、细腻、毛孔缩小、更有弹性。治疗效果评价：基本治愈8例（17．78％），显效25例（55．56％），好转11例（24．44％）．无效1例（2．22％），有效率为73．33％。结论大光斑低能量调Q开关1064nm激光治疗黄褐斑疗效确切．副作用小，安全性高。Objective To clarify the effectiveness of QS Nd ： YAG laser on melasma in Chinese patients. Methods A group （n=45） of patients previously diagnosed as facial melasma were treated with QS Nd ： YAG laser at approximately 1 week intervals. Eleven to twenty treatments were performed for each patient. The treatment efficacy of QS Nd ： YAG laser was evaluated by patients and doctors, respectively, at various time point such as before treatment, 5 weeks and 10 weeks after treatment and end of the treatment. The skin melanin index and the transepidermal water loss were evaluated by the skin multifunction tester at different time point, respectively. Results Compared with untreated, the melanin index of melasma areas decreased significantly after the laser treatment for 5 weeks, 10 weeks and the end of treatment. But there was no significant difference in the melanin index of normal skin areas with or without laser treatment. Compared with untreated, the transpidermal water loss of melasma areas increased significantly after the laser treatment for 5 weeks, 10 weeks and end of treatment. The patients＇ skin became smooth, delicate, pores shrink and more flexible. In 45 melasma patients treated by QS Nd ： YAG laser, 8 cases basically cured （17.78 %）, 25 cases were markedly effective （55.56 %）, 12 cases improved （24.44 %） and only 1 case was uneffective （2.22 % ）. The overall effective rate was 73.33 %. Conclusions QS Nd ： YAG laser is a useful treatment modality for Chinese women who have melasma with precise efficacy, less side effects and high safety.

关 键 词：黄褐斑 激光 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]