黄体中期补充戊酸雌二醇对IVF-ET结局的影响  

Influence of oestradiol valerate supplementation on pregnancy outcomes during mid-luteal phase in IVF-ET cycles

作　　者：张敏[1,2] 邱耀芳[1,2] 孙波澜[1,2] 叶丽霞[1,2] 吴小梅[1,2] 

机构地区：[1]深圳市第五人民医院 [2]罗湖区人民医院生殖医学中心,深圳518001

出　　处：《现代妇产科进展》2011年第9期707-709,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨黄体中期补充戊酸雌二醇对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法:采用回顾分析研究,选择2009年1月至11月及2010年1月至11月共772个黄体期长效促性腺激素释放激素激动剂(GnRHa)降调节后的常规IVF或卵胞浆内单精子注射(ICSI)周期(标准长方案),其中2009年399个周期于黄体中期不补充戊酸雌二醇作为对照组,2010年373个周期于黄体中期均补充戊酸雌二醇3～6mg作为实验组,再分别根据ET第7日与HCG日血清雌激素水平的比值分为4亚组(A,B,C,D组),比较4亚组周期的临床妊娠率、流产率。结果:各组妊娠率差异无统计学意义(P>0.05);ET第7日与HCG日血清雌激素水平的比值位于30%以下的组别(实验组的C,D亚组)于黄体中期补充戊酸雌二醇,其流产率较不补充戊酸雌二醇者明显降低(P<0.01)。结论:黄体中期补充戊酸雌二醇对IVF-ET结局无提高妊娠率的作用,但可降低流产风险。Objective：To evaluate the influence of oestradiol valerate supplementation on pregnancy outcomes during mid-luteal phase in IVF-ET cycles.Methods：772 long protocol IVF-ET or ICSI-ET cycles in 2009 and 2010（from January to November in each year）were retrospectively analyzed.The patients were divided into 4 groups（A,B,C,D）,according the ratio of E2 levels from the 7th day after embryo transfer to HCG administration.The patients from 2009 did not received oral oestradiol valerate during mid-luteal phase.The patients from 2010 received oral oestradiol valerate during mid-luteal phase.The rates of clinical pregnancy and abortion were compared among the groups in two years.Result：The rates of clinical pregnancy did not differ significantly among 4 groups in two years（P0.05）.The abortion rates of patients with 3～6mg/d of oestradiol valerate supplementation during mid-luteal phase in Group C and D（the ratio of E2 levels from the 7th day after embryo transfer to HCG administration is less than 30%）were lower than those patients who did not received oestradiol valeratein（P0.01）.Conclusions：Oestradiol valerate supplementation during mid-luteal phase cannot improve the rate of clinical pregnancy in IVF-ET,but can reduce the rate of abortion.

关 键 词：受精 体外 胚胎移植 雌激素 黄体中期 

分 类 号：R715.3[医药卫生—妇产科学]