柚皮苷对代谢综合征的改善及其机制研究  

Naringin improved the metabolic syndrome and its mechanism

作　　者：李睿[1] 饶国涛[1] 何荣华[1] 李朋[1] 黄从刚[1] 程俊[1] 邹永光[1] 

机构地区：[1]孝感市中心医院心内科,湖北孝感432100

出　　处：《临床心血管病杂志》2011年第10期779-783,共5页Journal of Clinical Cardiology

摘　　要：目的:研究柚皮苷对高脂饮食诱导的C57BL/6代谢综合征小鼠的治疗效果,进而探讨其作用机制。方法:以高脂饮食诱导20周的代谢综合征小鼠为模型,分析柚皮苷对模型小鼠一般情况、糖脂代谢、胰岛素抵抗、氧化应激的一系列指标的影响,同时探讨其作用机制。结果:经过20周的高脂饮食,小鼠形成了典型的代谢综合征的模型:肥胖、糖尿病、血脂异常、胰岛素抵抗,肝脏氧化应激明显升高。经过10周的药物干预,小鼠体重未减轻,但血糖得到控制、血脂明显下降、胰岛素抵抗得到缓解、肝脏抗氧化能力明显加强。分子生物学研究提示其降糖调脂效果可能与AMPK的激活和降低氧化应激能力相关。其中调脂效果是通过抑制脂质从头合成途径,增加脂质氧化代谢而发挥的。结论:柚皮苷能够很好的改善代谢综合征,这一作用可能与其激活AMPK蛋白和降低氧化应激相关。Objective：To explore the effects of a compound（naringin） on metabolic syndrome in mice and its molecular mechanisms.Methods：We used the high-fat diet to induce the mouse model.Then we analysed the metabolic index,such as general state of health,glycolipid metabolism,insulin resistance,oxidative stress,and explored the mechanisms of lipid-lowering effect.Results：The animal models,induced for 20 weeks,developed metabolic syndrome including obesity,dyslipidemia and insulin resistance.Addition of naringin for 10 weeks in diet attenuated the adverse outcomes except losing of body weight.Further study suggested that all the effects might be related to AMPK activation and attenutation of oxidative stress.And the lipid-lowering effect was achieved by inhibiting lipid synthesis de novo and increasing lipid oxidative metabolism.Conclusion：Naringin could significantly improve the symptoms of metabolic syndrome,which might be related to the activated AMPK and attenutation of oxidative stress.

关 键 词：代谢综合征 柚皮苷 氧化应激 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌]