围产期高盐饮食程控雄性子代大鼠动脉血压盐敏感性  

Blood pressure salt sensitivity in male offspring rats is programmed by perinatal high-salt diet

作　　者：吕波[1,2] 闫剑群[1] 刘健[2] 

机构地区：[1]西安交通大学医学院生理及病理生理系教育部环境与疾病相关基因重点实验室,陕西西安710061 [2]西安交通大学医学院机能实验中心,陕西西安710061

出　　处：《南方医科大学学报》2011年第10期1663-1668,共6页Journal of Southern Medical University

基　　金：国家自然科学基金(31000518);陕西省自然科学基础研究计划(2010JQ4001)~~

摘　　要：目的探讨围产期高盐饮食对子代Sprague-Dawley大鼠动脉血压及盐敏感性程控作用的性别差异及其可能机制。方法围产期给予高盐饮食(8%NaCl)和正常饮食(1%NaCl),监测雄性及雌性子代体重发育,并采用无创性尾套法测量血压及心率变化;后给予各组子代高盐饮食14 d观察其盐敏感性,并于测量结束后以放射免疫学方法检测血清及脑组织肾素-血管紧张素-醛固酮系统各成分及应激相关激素水平。结果围产期高盐饮食对子代大鼠青春期动脉血压无显著影响,但显著提高雄性子代的盐敏感性,且雄性子代血清血管紧张素II升高,而肾上腺皮质激素释放激素和皮质醇低于正常组,雌性子代则未观察到相同效应。结论围产期高盐饮食对子代动脉血压盐敏感性具有程控作用,并具有显著的性别差异,其机制可能与子代肾素-血管紧张素-醛固酮系统功能异常及应激反应性变化有关。Objective To investigate the gender differences in perinatal high-salt diet programming of blood pressure and salt sensitivity in offspring Sprague-Dawley rats and explore the mechanisms.Methods The rats were fed with high-salt diet（8% NaCl） or normal salt diet（1% NaCl） during the perinatal period.Body weight changes were monitored,and blood pressure and heart rate were measured by non-invasive tail-cuff methods in both male and female offspring rats.The components of renin-angiotensin-aldosterone system（RAAS） in both the serum and brain tissue,and hormones related with stress reaction were detected using radioimmunology methods.Results Perinatal high-salt diet did not affect adolescent blood pressure in both genders,but significantly increased salt sensitivity in male offspring rats.Perinatal high-salt diet also increased serum angiotensin II（ANG II） while decreased corticotropin-releasing hormone（CRH） and cortisol in male offsprings,as compared with the normal salt diet group.No similar results were found in the female offspring rats.Conclusion There is a significant gender difference in perinatal high-salt diet programming of offspring blood pressure salt sensitivity,and the mechanisms may involve the disturbance of the RAAS function and stress reaction.

关 键 词：围产期 高盐饮食 子代 血压 盐敏感性 肾素-血管紧张素-醛固酮系统 

分 类 号：R544.1[医药卫生—心血管疾病]