8种环境内分泌干扰物对多囊卵巢综合征胰岛素抵抗的影响  

Effects of eight environmental endocrine disruptors on insulin resistance in patients with polycystic ovary syndrome:a preliminary investigation

作　　者：李婷婷[1] 许良智[1] 陈永亨[2] 邓红梅[2] 梁春营[2] 刘颖[1] 刘晓芳[1] 张静 康德英[3] 邱东升[4] 韩代文[4] 胡蓉[4] 

机构地区：[1]四川大学华西第二医院妇产科,四川成都610041 [2]广州大学环境科学与工程学院,广东广州510006 [3]四川大学华西医院,四川成都610041 [4]四川大学华西第二医院检验科,四川成都610041

出　　处：《南方医科大学学报》2011年第10期1753-1756,1777,共5页Journal of Southern Medical University

基　　金：四川省卫生厅科学研究项目(100377;060020;090289)

摘　　要：目的通过检测多囊卵巢综合征(PCOS)患者血中8种环境内分泌干扰物,初步探讨其与PCOS胰岛素抵抗的关系。方法分别测定60例PCOS患者(PCOS-IR组23例和PCOS-NIR组37例)及29例输卵管性不育、男性不育、月经紊乱原因就诊非PCOS非胰岛素抵抗对照组血清中的六种邻苯二甲酸酯类(PAEs)、双酚A(BPA)及辛基酚(OP)的含量,SPSS16.0软件进行统计分析。结果六种PEAs、BPA在PCOS与非PCOS对照组间以及PCOS-IR与PCOS-NIR之间差异均无明显统计学意义(P>0.05)。OP在PCOS与非PCOS对照组间差异无明显统计学意义(P>0.05),但在PCOS-IR与PCOS-NIR之间差异有统计学意义(P<0.05),且OP在PCOS-IR组含量低于在PCOS-NIR组含量。结论 PEAs、BPA对PCOS的发病及胰岛素抵抗无明显影响,OP则可能对PCOS胰岛素抵抗有影响。Objective To investigate the relationship between 8 endocrine-disrupting chemicals in the serum and insulin resistance in patients with polycystic ovary syndrome（PCOS）.Methods This study was conducted among 60 patients with PCOS,including 23 with insulin resistance（PCOS-IR） and 37 without insulin resistance（PCOS-NIR）,and 29 non-PCOS women seeking medical attention for infertility or menstrual disorder（control group）.The serum levels of 6 phthalic acid esters（PEAs）,bisphenol A（BPA） and octylphenol（OP） were measured in all the subjects.Results The levels of PAEs,BPA and OP showed no significant differences between PCOS patients and the control group（P0.05）.The serum level of OP was significantly lower in patients PCOS-IR than in those with PCOS-NIR（47.89 ng/ml vs 60.24 ng/ml,P0.05）.Conclusion PEAs and BPA do not produce obvious effect on the pathogenesis of PCOS or contribute to insulin resistance,but OP may play a role in insulin resistance in PCOS patients.

关 键 词：环境内分泌干扰物 多囊卵巢综合征 胰岛素抵抗 双酚A 辛基酚 邻苯二甲酸酯 

分 类 号：R711.75[医药卫生—妇产科学]