磁性白蛋白纳米微粒的制备及其物理性能分析  

Preparation of magnetic albumin nanoparticles and analysis of their physical property

作　　者：于耀宇[1] 李建[1] 李立宏[1] 曲友直[1] 于嘉[1] 邓建平[1] 高国栋[1] 张文彬[2] 焦德让[2] 

机构地区：[1]第四军医大学唐都医院神经外科,西安710038 [2]中国人民武装警察部队医学院附属医院神经外科,天津300162

出　　处：《中国临床神经外科杂志》2011年第10期609-611,共3页Chinese Journal of Clinical Neurosurgery

基　　金：国家自然科学基金(NO:30772220);天津市自然科学基金(NO:07JCYBJC10400)

摘　　要：目的探讨磁性白蛋白纳米微粒（MAN）的制备方法及其物理性能。方法用热处理法将人血白蛋白分散在纳米磁性微粒（Fe3O4）中,并加入表面活性剂——聚丙烯酸,在超声激烈搅拌下加热,使人血白蛋白稳定,得到人浆白蛋白包裹的生物相容MAN。结果实验制备出MAN具有纳米级的大小、尺寸和形状,扫描电镜和粒径测试仪测试MAN直径为100~1000nm,且具有确切的磁响应性、磁特性、靶向性和分散性等性能。结论用热处理法可以制备出纳米级具有磁响应性、磁特性、靶向性和分散性的生物相容的MAN。Objective To explore the method to prepare the magnetic albumin nanoparticles （MANs） and their physical property. Method The magnetic nanoparticles （Fe 3 O 4 ） were made by putting surface active agent, polyacrylic acid in the mixed solution of FeCl 3 and FeCl 2 , centrifugalition and drying. The human plasma albumin was dispersedin the magnetic nanoparticles and covered the magnetic nanoparticles by the heat treatment and stir with ultrasound in order to prepare biocompatible MANs. The physical property of MANs was determined. Results The biocompatible MANs which had the diameter of 100~1 000 nm were successfully prepared. The MANs had good magnetic responsibility, magnetic character, targeting and dispersibility. Conclusions The biocompatible MANs which have good magnetic responsibility, magnetic character, targeting and dispersibility may be prepared by putting polyacrylic acid in the mixed solution of FeCl 3 and FeCl 2 and the heat treatment which make the human plasma albumin cover the magnetic nanoparticles.

关 键 词：磁性白蛋白纳米微粒 制备 方法 物理性能 

分 类 号：R318.08[医药卫生—生物医学工程]