小间隙套接修复周围神经技术及新型套接材料  

Small-gap bridging technology for peripheral nerve injury repair and the new sleeve material

作　　者：寇玉辉[1] 殷晓峰[1] 张培训[1] 姜保国[1] 

机构地区：[1]北京大学人民医院创伤骨科,北京大学交通医学中心,北京100044

出　　处：《北京大学学报（医学版）》2011年第5期647-651,共5页Journal of Peking University:Health Sciences

基　　金：国家杰出青年科学基金(30625036);国家自然科学基金(30801169,30971526,30973066);北京市科技新星(A-2008-10)项目资助~~

摘　　要：周围神经损伤是临床常见创伤,许多病例致伤后终生残疾。影响治疗效果的关键因素是损伤的神经是否得到良好的再生,而缝接技术是神经再生的最重要基础。近百年来,全世界在临床上一直沿用的神经外膜缝合方法,由于无法使神经干内数千条不同性质的神经纤维准确对接,在很大程度上影响着神经的修复效果。与此同时,研究发现再生的神经纤维能够选择性长入与其性质相同的远端神经,即周围神经选择性再生现象。SUMMARY The peripheral nerve injury is a common injury in clinical practice.For centuries,traditional epineurial and perineurial suture techniques have been used to repair nerve transection after peripheral nerve injuries.As there are several types of nerve fibers in neural stump,accurate and effective regenera-tion of the fibers is limited.The outcome of repairing nerve injury has little improvement till now.Mean-while,the selective regeneration of peripheral nerve fibers has been gradually confirmed by researchers.The limitation of traditional epineurial and perineurial suture techniques and the pheno-menon of selective regeneration of nerve fibers had inspired us with the creative idea： the small gap brid-ging suture tech-niques,which might take the place of the conventional epineurial and perineurial suture methods.Wehad made a series of detailed studies about this new method,devised a simple and reliable suture method and established an animal model of small-gap bridging suture technique.By observing peripheral nerve regeneration effect of nerve suture with small-gap bridging by different gap lengths,we found that the op-timal gap was between 1 to 3 mm,developed an artificial conduit with good biocompatibility and gradually applied this new conduit to mammals and primate animal experiments and clinical trials.All the studiesobtained reliable results,which confirmed that the small-gap bridging suture was suitable to replace thetraditional epineurium suture repairing the peripheral nerve injury.In 2010,this series of research gained the First Prize of Outstanding Scientific Achievement Award by the Ministry of Education.

关 键 词：周围神经 神经再生 缝合技术 

分 类 号：R651.3[医药卫生—外科学]