2型糖尿病合并高血压患者胰岛素抵抗与C反应蛋白、肿瘤坏死因子的关系研究  

Study of correlation between C-reactive protein,tumor necrosis factor-alpha and insulin resistance in patients with type 2 diabetes with hypertension

作　　者：张天弼[1] 冯慧斌[1] 林斌[1] 杜雪霞[1] 陈小龙[1] 吴明清[1] 

机构地区：[1]汕头大学医学院附属粤北人民医院综合内科,韶关512026

出　　处：《中国实用医药》2011年第27期6-7,共2页China Practical Medicine

摘　　要：目的探讨2型糖尿病合并高血压患者胰岛素抵抗与C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)的关系。方法设正常组50例,糖尿病合并高血压患者组60例。检测患者血清空腹胰岛素、C肽、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)水平及胰岛素抵抗指数(HOMA-IR)程度。结果糖尿病合并高血压患者组与正常组C反应蛋白(CRP)、肿瘤坏死因子(TNF-α),胰岛素抵抗指数(IR)相比,差异有统计学意义(P<0.001)。结论 2型糖尿病合并高血压患者胰岛素抵抗与C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)显著呈正相关。Objective To explore the relationship between C-Reactive protein tumor necrosis factor-al- pha and insulin resistance in patients with type 2 diabetes with hypertension. Methods C-reactive protein, tumor necrosis factor-alpha, and insulin resistance levels in the 60 patients with type 2 diabetes with hypertension and 50 normal controls were detected. Results The type 2 diabetes with hypertension group C-reactive protein, tumor necrosis factor-alpha, HOMA-IR, the normal control group C-Reactive protein, tumor necrosis factoralpha, HOMA-IR,the type 2 diabetes group showed significant diference than the normal control group （P 〈 0. 001 ）. Conclusion The C-reactive protein, tumor necrosis factor-alpha are positively correlated with insulin resistance in type 2 diabetes patients with hypertension.

关 键 词：2型糖尿病 C反应蛋白 肿瘤坏死因子-Α 胰岛素抵抗指数 

分 类 号：R587.1[医药卫生—内分泌]