类风湿关节炎实验诊断指标的比较分析  

Comparative analysis of laboratory indexes for rheumatoid arthritis

作　　者：邵耀明[1] 倪芳颖[1] 陈国千[1] 

机构地区：[1]南京医科大学附属无锡人民医院医学检验科,江苏无锡214023

出　　处：《中国实验诊断学》2011年第10期1655-1656,共2页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金资助(81070074)

摘　　要：目的调查抗环瓜氨酸肽(CCP)抗体和类风湿因子在类风湿关节炎实验诊断中的敏感性、特异性和结果相关性。方法对健康体检者102例、类风湿关节炎患者128例和非类风湿关节炎患者151例的抗CCP抗体和类风湿因子检测结果进行统计分析。抗CCP抗体采用ELISA法检测,类风湿因子采用免疫比浊法检测。结果抗CCP抗体和类风湿因子对于类风湿关节炎的敏感性分别为76.6%、86.7%(P<0.05),特异性分别为94.9%、69.9%(P<0.01)。类风湿关节炎患者抗CCP抗体和类风湿因子定量检测结果之间的相关系数为0.187(P>0.05)。抗CCP抗体、类风湿因子阳性率在不同性别或年龄之间均无显著性差别(P>0.05)。结论抗CCP抗体对类风湿关节炎的特异性明显优于类风湿因子,而敏感性略低;抗CCP抗体与类风湿因子定量检测结果间无显著相关性。Objective To investigate the sensitivity and specificity of anti-CCP antibody and rheumatoid factor in laboratory diagnosis of rheumatoid arthritis,and their correlation.Methods Determination results of anti-CCP antibody and rheumatoid factor were statistically analysed in 102 healthy subjects,128 cases with rheumatoid arthritis and 151 patients without rheumatoid arthritis.Anti-CCP antibody and rheumatoid factor were detected by ELISA and immunoturbidimetry,respectively.Results The sensitivity of Anti-CCP antibody and rheumatoid factor for rheumatoid arthritis was 76.6% and 86.7%（P0.05）,specificity 94.9% and 69.9%（P0.01）,respectively.The correlation coefficient between the quantitative results of anti-CCP antibody and rheumatoid factor was 0.187（P0.05）in rheumatoid arthritis.The positive rate of anti-CCP antibody or rheumatoid factor showed no significant difference between different sex or age.Conclusion The specificity of anti-CCP antibody is markedly better than rheumatoid factor for rheumatoid arthritis,as the sensitivity is reverse.No significant correlation is found in the quantitative results between anti-CCP antibody and rheumatoid factor in rheumatoid arthritis.

关 键 词：类风湿关节炎 类风湿因子 抗环瓜氨酸肽抗体 

分 类 号：R593.22[医药卫生—内科学]