红霉素诱导呼吸道分离金黄色葡萄球菌耐药状况研究  

Study on Staphylococcus aureus from respiratory tract resistance induced by erythromycin

作　　者：王轶[1] 刘珊珊[1] 黄瑾[2] 

机构地区：[1]中山大学附属第五医院ICU,广东珠海519000 [2]中山大学附属第五医院呼吸科,广东珠海519000

出　　处：《中国实验诊断学》2011年第10期1719-1720,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨呼吸道分离的金黄色葡萄球菌耐药情况、耐药的菌株是否有遗传稳定性,及对其他种类的抗生素有无交叉耐药。方法把试验菌株与标准菌株在不同含药平皿中接种传代,观察MIC值的变化,再测定遗传稳定性及有无交叉耐药。结果试验菌株与标准菌株多次传代后,耐药突变菌株获得的耐药性是稳定的。未对其他种抗生素发生交叉耐药。结论合理选用抗生素,监测细菌耐药性、掌握耐药机制等综合措施的实施,才能减缓细菌耐药性的增长。Objective To know that resistance of Staphylococcus.And whether the strains has cross-resistance to other kinds of antibacterials,so as to offer reference to clinician.Methods The strains were induced in the serial of agar plates.Then we observed the change of MIC.Then we detected whether the mutation strain could inherit stably.and whether they displayed cross-resistant.Results The mutations stains were found to be genetically stable.The strains didn＇t have cross-resistance to other antibiotics.Conclusion At present clinician use antibiotic reasonably,it can reduce drug resistant strains.

关 键 词：金黄色葡萄球菌 红霉素 诱导耐药 交叉耐药 

分 类 号：R446.5[医药卫生—诊断学]