血清抑制素B在男性不育症诊断中的应用研究  

Applicable value of serum inhibin B in infertile men

作　　者：刘琼珊 李长祺 林敏 黄以兰 车敏 郑云忠 

机构地区：[1]福建省人口和计划生育科学技术研究所,福州350011

出　　处：《福建医药杂志》2011年第5期5-6,59,共3页Fujian Medical Journal

基　　金：福建省属公益类科研院所基本科研专项计划项目(2009R10019-1)

摘　　要：目的探讨不育男性血清抑制素B测定的临床价值。方法采用酶联免疫吸附法(ELISA)检测少精子症组(A组,51例)、梗阻性无精子症组(B组,45例)、非梗阻性无精子症组(C组,44例)及正常对照组(D组,85例)血清抑制素B(INHB)浓度。结果 A、B、C、D组INHB浓度分别为(109.9±47.61)pg/ml、(171.7±56.36)pg/ml、(57.32±15.56)pg/ml及(164.58±47.93)pg/ml。与D组相比,A组、C组血清INHB浓度明显降低(P<0.01);B组与D组的差异无统计学意义(P>0.05)。与B组相比,C组血清INHB浓度显著低下(P<0.01)。结论血清抑制素B测定可用于评价男性不育病人的生精功能,也是鉴别梗阻性和非梗阻性无精子症的一项重要指标。Objective To study the diagnostic value of serum inhibin B in infertile men. Methods There were 51 oligospermia, 45 obstructive and 44 nonobstructive azoospermia infertile men selected as the study group （group A, B, C） and 85 health men as the control group （group D） . The levels of serum inhibin B （INHB） were measured by ELISA. Results The levels of serum INHB were （109.9±47.61） pg/ml, （171. 7±56. 36） pg/ml, （57.32±15.56） pg/mland （164.58±47.93） pg/ml in group A, B, C, D, respectively. Group A and C had significantly lower levels of serum INHB than group D （P〈 0.01）. There was no significant statistical differences in Group B and C （P〉0.05）. Group C had significantly lower level of serum INHB than group B （P〈0.01）. Conclusion The determination of INHB in males can be used to assess the spermatogen- esis of infertile men. It is also an important marker of azoospermatism differential diagnosis.

关 键 词：男性不育 血清抑制素B 酶联免疫吸附法 临床价值 

分 类 号：R698.2[医药卫生—泌尿科学] R446.119[医药卫生—外科学]