肿瘤干细胞生长相关的信号转导通路  

Growth Signaling Pathways of Cancer Stem Cells

作　　者：王洋[1] 张楠[1] 刘艳[1] 刘晶[2] 叶福秀 邹伟[4] 

机构地区：[1]辽宁师范大学生命科学学院,大连116021 [2]大连医科大学中英再生医学应用研究中心,大连116011 [3]大连市第五人民医院,大连116021 [4]辽宁师范大学辽宁省生物技术和分子药物研发重点实验室,大连116029

出　　处：《中国生物化学与分子生物学报》2011年第10期920-924,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.30970353)项目资助~~

摘　　要：肿瘤干细胞是肿瘤中存在的一小群具有自我更新和分化潜能的细胞,也是存在于肿瘤组织中具有干细胞样能力的肿瘤细胞亚群,在肿瘤的发生、发展中起着非常重要的作用.近年来发现,肿瘤干细胞的生长调控与Wnt、Notch、Hedgehog等多种信号转导通路有关.本文简要综述了肿瘤干细胞生长相关信号转导通路的研究进展,旨在为肿瘤干细胞研究和临床应用提供理论依据.Cancer stem cells（CSCs） are the small population of cells involved in tumor possessing renewal and differentiation properties,also known as the stem cell-like cell subpopulations in tumors,which play an important role in tumor occurrence and development.Recent discoveries revealed that the growth regulation of tumor cells was significantly related to the Notch,Wnt and Hedgehog signaling pathways,etc..To provide a theoretical basis for CSCs research and clinical application,we briefly reviewed the research advancements of the signal transduction pathways related to CSCs growth.

关 键 词：肿瘤 肿瘤干细胞 信号转导通路 

分 类 号：Q291[生物学—细胞生物学]