IFN-γ基因+874位点基因多态性与肺结核易感性的病例对照研究  

Correlation between the genetic polymorphism of IFN-γ+874 site and susceptibility to pulmonary tuberculosis in patients with TB and healthy subjects

作　　者：王海宾[1] 国文 杨淑岭[1] 康书慧[1] 刘海云[1] 曹金凤[1] 田红卫[1] 檀新云 刘玉肖[1] 

机构地区：[1]河北省石家庄市第五医院 [2]武警疾病预防控制中心 [3]河北省栾城县疾病预防控制中心

出　　处：《河北医药》2011年第21期3220-3222,共3页Hebei Medical Journal

摘　　要：目的探讨干扰素-γ(IFN-γ)基因多态性与中国汉族人群肺结核发病间的关系。方法采用病例对照研究设计,应用扩增难控性突变系统PCR法检测(ARMS-PCR)病例组(n=273)及对照组(n=279)IFN-γ基因+874位点的基因型,同时开展对结核病相关环境危险因素进行问卷调查。结果 +874位点各基因型在2组中的分布差异无统计学意义(P>0.05)。多因素分析中调整了接触史和卡介苗接种史后,+874基因型仍与肺结核发病无显著关联。结论 IFN-γ+874位点基因多态性可能与中国汉族人群肺结核发生的易感性无显著关联。Objective To investigate the association between the IFN-γ ＋ 874 site genetic polymorphisms and pathogenesis of pulmonary tuberculosis （TB） in Chinese Han population. Methods A case-control study was adopted, and the ARMS-PCR analysis was used to determine the genotype of IFN-γ＋ 874 site in case group （ n = 273） and control group （279）. At the same time,the questionnaire investigation about TB-related environment risk factors was performed. Results There were no significant differences in different genotypes at IFN-γ ＋ 874 site between the two groups （ P 〉 0.05）. After the exposure history and BCG vaccination history were adjusted the muhifactor analysis showed the genotypes at IFN-γ ＋ 874 site were still not correlated with the pathogenesis of pulmonary TB. Conclusion The IFN-γ＋ 874A/T genetic polymorphism may be not obviously related with the pathogenesis of pulmonary TB in Chinese Han population.

关 键 词：肺结核 IFN-Γ基因 病例对照研究 

分 类 号：R521[医药卫生—内科学]