CT/MRI双模态造影剂的制备和表征  

Synthesis and characterization of dual modality contrast agent for CT/MRI imaging

作　　者：王月花[1] 宋丽娜[1] 丁佳丽[1] 鲁珊珊[2] 蒋燕妮[2] 张宇[1] 顾宁[1] 

机构地区：[1]东南大学生物科学与医学工程学院生物电学国家重点实验室江苏省生物材料与器件重点实验室,江苏南京210096 [2]江苏省人民医院放射科,江苏南京210029

出　　处：《东南大学学报（医学版）》2011年第5期671-675,共5页Journal of Southeast University(Medical Science Edition)

基　　金：国家自然科学基金资助项目(30870679;30970787;60725101);国家重大科学研究计划项目(2011CB933503)

摘　　要：目的:合成用于CT/MRI双模态造影的水包油型纳米乳液,并对其进行表征。方法:用共沉淀法合成油酸包裹的Fe3O4纳米颗粒,然后将其分散到市售的碘化油注射液中,借助纳米乳液的合成方法合成出CT/MRI双模态造影剂,并用透射电镜(TEM)、动态光散射(DLS)、水平磁场作用下乳滴的组装、CT和MRI等方法进行表征。结果:(1)TEM结果显示,乳滴的直径约为100 nm,DLS测得其水动力尺寸平均为81.7 nm;(2)将乳液置于水平磁场作用下验证了Fe3O4纳米颗粒确实存在于乳滴内;(3)CT、MRI等分析手段显示了该乳液的CT值为292.6 HU(碘含量为24 mg.ml-1),弛豫率为65.7 mmol.L-1.s-1。结论:CT/MRI双模态造影的水包油型纳米乳液具有良好的CT和MRI造影增强效果,有望成为一种性能优异的CT/MRI双模态造影剂。Objective： To synthesis a kind of oil-in-water nanoemulsion for dual modal CT/MRI imaging and characterize it.Methods： Using coprecipitation method to synthesis oleic acid coated Fe3O4 nanoparticles,and dispersed them into iodinated oil injection.CT/MRI dual modality contrast agent was prepared on the basis of nanoemulsion formation,which was characterized by TEM,DLS,assembly of nanodroplets under a horizontal magnetic field,CT and MRI.Results：（1） TEM results revealed that the nanoemulsion had a size of 100 nm.DLS study showed the hydrodynamic mean diameter was 81.7 nm,approximately.（2） Placing the nanoemulsion under a horizontal magnetic field showed Fe3O4 nanoparticles existed in the droplets.（3） CT and MRI measurements showed the CT value was 292.6 HU（iodine concentration： 24 mg·ml-1）,and the relaxibility value（r2） of the nanoemulsion was 65.7 mmol·L-1·s-1.Conclusion： This kind of oil-in-water nanoemulsion enhances prominently CT and MRI contrast,which is expected to become an excellent dual modality contrast agent for CT/MRI imaging.

关 键 词：体层摄影术 X线计算机 磁共振成像 双模态 FE3O4纳米颗粒 纳米乳液 

分 类 号：R814.49[医药卫生—影像医学与核医学] O647.9[医药卫生—放射医学]