子痫前期患者外周血淋巴细胞CD28/CTLA-4的表达水平及意义  

Expression and significance of CD28/CTLA-4 in peripheral in preeclampsia

作　　者：王莲莲[1] 罗娜[1] 曹霞[1] 

机构地区：[1]中国医科大学附属第四医院产科,辽宁沈阳110032

出　　处：《东南大学学报（医学版）》2011年第5期748-750,共3页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:探讨子痫前期外周血淋巴细胞CD28/CTLA-4的表达水平与子痫前期发病的相关性。方法:选择住院确诊的子痫前期孕妇35例为实验组,以30例正常妊娠晚期孕妇为对照组,应用流式细胞术检测两组外周血CD28和CTLA-4在CD3+T细胞上的表达水平并比较。结果:实验组孕妇外周血CD28的表达水平较对照组差异无统计学意义(P>0.05);CTLA-4表达水平显著高于对照组,差异有统计学意义(P<0.05);实验组中外周血CD28/CTLA-4值较对照组降低,差异有统计学意义(P<0.05)。结论:子痫前期患者外周血CD28/CTLA-4表达异常,从而使T细胞亚群分类异常,免疫调节功能紊乱,免疫耐受失衡,导致子痫前期的发生。Objective： To study the relationship between the expression of CD28/CTLA-4 in peripheral and the mechanisms of preeclampsia.Methods： 35 PE patients with preeclampsia selected as preeclampsia group and 30 normal pregnant women as controls were investigated,followed by a comparison of the expyession of CD28/CTLA-4 in peripheral by flow cytometry.Results： There was no statistical difference in the expression of CD28 between the two groups（P0.05）.There was a statistical difference of the levels of CTLA-4 between the two groups（P0.05）,and patients with preeclampsia in CD28/CTLA-4 ratio lower than normal control group,the difference was statistically significant（P0.05）.Conclusion： The abnormal expression of CD28/CTLA-4 in patients with preeclampsia can lead to abnormal category in T cell subsets,the dysfunction of maternal-fetal immune regulation,the immune tolerance imbalance,and the occurrence of preeclampsia.

关 键 词：抗原 CD28 抗原 CTLA-4 子痫前期 流式细胞术 

分 类 号：R714.24[医药卫生—妇产科学]