内脂素、NT-proBNP水平及左心房内径与持续性房颤的相关性研究  

The correlative study of plasma visfatin,NT-proBNP and left atrial diameter in atrial fibrillation patients

作　　者：于红玖[1] 赵敏[1] 秦宇[1] 吕田[1] 

机构地区：[1]大连医科大学附属第一医院特需医疗部,辽宁大连116011

出　　处：《重庆医学》2011年第31期3143-3144,3146,共3页Chongqing medicine

摘　　要：目的研究房颤患者血浆内脂素、氨基末端B型脑钠肽前体(NT-proBNP)、左心房内径(LAD)的变化,探讨其临床意义。方法选择46例符合诊断要求的心内科住院房颤患者,分为阵发性房颤组(房颤持续时间小于7d,n=22)和持续性房颤组(房颤持续时间大于或等于7d,n=24),另选择同时期心内科住院无房颤患者(n=15)作为对照组,比较各组间内脂素、NT-proBNP、LAD变化。结果持续性房颤组与阵发性房颤组和对照组比较,内脂素、NT-proBNP水平明显升高,LAD明显增大(P<0.05);阵发性房颤组和对照组内脂素、NT-proBNP水平以及LAD比较差异无统计学意义(P>0.05);内脂素水平与LAD呈正相关。结论内脂素、NT-proBNP水平以及LAD与房颤的持续性有关,可以用来预测房颤的转归,指导房颤治疗。Objective To evaluate the significance of visfatin,NT-proBNP levels and left atrial diameter（LAD） in atrial fibrillation（AF） patients.Methods 46 AF patients were divided into two groups,paroxysmal AF group（n=22） and persistent AF group（n=24）.Control group including 15 patients who were admitted to hospital in cardiology department without AF.Plasma visfatin,NT-proBNP levels and LAD were measured and compared among the three groups.Results Visfatin,NT-proBNP levels and LAD in persistent AF group were significantly higher than those in control group and paroxysmal AF group,while there were no difference between paroxysmal AF group and control group.Plasma visfatin level was positively correlated with LAD.Conclusion The elevation of plasma visfatin,NT-proBNP levels and LAD were associated with the genesis and perpetuation of AF.

关 键 词：心房颤动 烟酰胺磷酸核糖基转移酶 B型脑钠肽 左心房内径 

分 类 号：R541.75[医药卫生—心血管疾病]