钙通道阻滞剂对新生儿缺氧缺血性脑病血清钙、NO、IL-18的影响及相关性研究  

Effects of Calcium Entry Blocker(nimodipine)on serum Ca^(2+) and NO and IL-18 in neonatal hypoxic ischemic encephalopathy(HIE)

作　　者：杨小巍[1] 柏金秀[1] 姬静璐[1] 李少华[1] 贾浩[1] 许月红[1] 

机构地区：[1]河北大学附属医院儿科,河北保定071000

出　　处：《医学研究与教育》2011年第5期14-17,共4页Medical Research and Education

基　　金：河北省科技攻关项目(072761416)

摘　　要：目的通过监测钙通道阻滞剂尼莫地平干预下,新生儿缺氧缺血性脑病(HIE)患儿血清钙、NO及IL-18的变化,观察尼莫地平对HIE患儿病情缓解的积极作用,说明尼莫地平在治疗HIE中具有很好的应用前景及临床价值。方法将尼莫地平治疗组、常规治疗组、对照组分别于生后1d、3d、7d、14d检测血清钙、NO、IL-18。结果 HIE患儿生后第1天Ca2+含量较对照组降低,血清NO及IL-18含量较对照组均有升高,对比有统计学意义(P<0.01);且中、重度HIE患儿Ca2+含量低于轻度HIE患儿,血清NO及IL-18含量明显高于轻度HIE患儿,对比有统计学意义(P<0.01);经尼莫地平治疗的HIE患儿生后血清Ca2+、NO及IL-18含量恢复正常时间明显早于常规治疗组,对比有统计学意义(P<0.01)。结论血清Ca2+、NO及IL-18含量与病情的严重程度相关,可以作为HIE病情变化的监测指标;尼莫地平可降低HIE所致的脑细胞损伤,提高对HIE的治疗疗效。Objective To monitor the level changes of Ca2＋and NO and IL-18 in neonatal HIE with nimodifine utilization and observe the effective actions of nimodifine on alleviating the patients＇ condition. Methods The patients were divided into Nimodifine group and regular therapy group, normal neonates were chosen to be as a control group. In each group, the concentrations of Ca2~and NO and IL-18 were tested on 1 day, 3 days, 7 days and 14 days. The changes and significances of Ca2＋and NO and IL- 18 were analysed. Results The levels of serum NO and IL-18 in HIE groups on the first day after birth were higher than those of the control group, but Ca2~were lower （P〈0.01）. The levels of NO and IL-18 in patients with moderate and severe HIE were much higher than those of patients with mild HIE, but Ca2~were lower （P〈0.01）. The treatment time for reducing higher levels of Ca2~and NO and IL-18 to normal limit in the nimodifine group was much shorter than that of the regular therapy group （P〈0.01）. Conclusion The levels of Ca2＋and NO and IL-18 in HIE patients are positively correlated with the severity of condition, whereby they may be acted as indicators for monitoring the conditonchanges. Nimodifine shortens the treatment time for reducing the levels of Ca2＋and NO and IL-18 to normal limit in HIE patients compared with regular therapy without obvious side-effects.

关 键 词：钙通道阻滞剂 血清钙 NO IL-18 新生儿 缺氧缺血 

分 类 号：R72[医药卫生—儿科]