3-甲基噻吩溴化物的合成与表征  

Synthesis and characterization of 3-methylthiophene bromides

作　　者：刘福德[1] 王娟[1] 王萍[1] 王春英[1] 赵立娟[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《天津工业大学学报》2011年第5期42-45,共4页Journal of Tiangong University

摘　　要：以3-甲基噻吩及NBS为原料,合成得到2-溴-3-甲基噻吩和2,5-二溴-3-甲基噻吩;确定气相色谱检测方法,并通过气相色谱检测反应进程确定反应终点.结果表明:当反应温度为40℃、反应时间为8.5 h时,2-溴-3-甲基噻吩收率为87%,产品纯度大于98%(GC);当回流反应11 h时,2,5-二溴-3-甲基噻吩收率为78%,产品纯度大于98%(GC).IR、1H NMR表征表明所得产品结构正确.With 3-methylthiophene and NBS as basic materials,2-bromo-3-methylthiophene and 2,5-dibromo-3-methylthiophene are synthesized.The method for analysing the concentration of reactant and product in solution by GC is given,and the reaction proceeding is determined by GC.The results show that when the reaction time is 8.5 h,reaction temperature is 40 ℃,the yield of 2-bromo-3-methyl thiophene is 87%,the purity is above 98%（GC）.On the other hand,when the reaction time is 11 h at reflux,the yield of 2,5-dibromo-3-methylthiophene is 78%,the purity is above 98%（GC）.The above products are characterized by IR and 1H NMR.

关 键 词：3-甲基噻吩 溴化物 2-溴-3-甲基噻吩 2 5-二溴-3-甲基噻吩 

分 类 号：TQ031.2[化学工程]