消骨增贴基质配方工艺  

Matrix Formulation Technology of Xiaoguzeng Patch

作　　者：闫荟[1] 王苏会[1] 谢予朋[1] 孙世光[1] 杨锋[1] 孙晓迪[1] 史琪荣[1] 张京[1] 刘建华[2] 

机构地区：[1]北京军区总医院药剂科,北京100700 [2]北京军区总医院保健科,北京100700

出　　处：《中国实验方剂学杂志》2011年第21期26-29,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:优选消骨增贴基质配方工艺。方法:通过L18(37)正交设计试验,以配方中NP700,甘油,EDTA,PVPPXL-10,甘氨酸铝,PVPK90,药液为因素,其用量为水平,以黏着力、膜残留性、综合指标为考察指标。结果:对黏着力影响最大的是NP700,甘油次之,且他们对黏着力均有显著影响。对膜残留性和综合指标影响最大的是PVPPXL-10。巴布剂基质的最优配方为NP700-甘油-EDTA-PVPPXL-10-甘氨酸铝-PVPK90-药液(6∶30∶0.025∶1∶0.05∶1∶20)。结论:该工艺条件简便易于产业化,按优化后的基质处方制备的凝胶膏剂基质黏性优良,膜残留性低,外观平整光滑,符合药用标准。Objective：To optimize matrix formulation process of Xiaoguzeng patch.Method： L18（37） orthogonal test was designed,NP700,glycerol,EDTA,PVPPXL-10,aluminum glycinate,PVPK90 and liquid medicine as factor,dosage of these as lever.Adhesion force,membrane residues and composite indicator were considered as index.Result： The greatest impact on adhesion force was NP700,followed by glycerol,and they had a significant effect on adhesion force.The greatest impact on membrane residues and composite indicator was PVPPXL-10.Optimum matrix formulation of Xiaoguzeng patch was NP700-glycerol-EDTA-PVPPXL-10-aluminum glycinate-PVPK90-liquid medicine as 6∶30∶0.025∶1∶0.05∶1∶20.Conclusion： This process was simple and easy to industrialization.Prepared by optimum matrix formulation,gel ointment matrix shows good viscosity viscidity and lower membrane residues,smooth appearance,conformed to medicinal standard.

关 键 词：消骨增贴 凝胶膏剂 基质 正交试验 

分 类 号：R283.6[医药卫生—中药学]