益母草总碱对小鼠前列腺增生模型的影响  

Effect of Total Alkaloids Extracted from Leonuri Herba on Mice Benign Prostate Hyperplasia

作　　者：刘绍龑[1] 白明[1] 纪晓宁[1] 张颖[1] 苗明三[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中国实验方剂学杂志》2011年第21期177-180,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81173474);郑州市科技领军人才项目(0910SGYS3527)

摘　　要：目的:探讨益母草总碱对小鼠前列腺增生模型的影响。方法:昆明种雄性小鼠连续3周sc丙酸睾酮5 mg.kg-1.d-1,造前列腺增生模型,将模型小鼠分为5组,分别ig 160,80,40 mg.kg-1的益母草总碱液,450 mg.kg-1癃闭舒胶囊混悬液和同体积的生理盐水,另设一组空白组给同体积生理盐水;每天给药1次,连续给药30 d。末次给药1 h后处死小鼠,观察益母草总碱对前列腺指数,对前列腺、睾丸、附睾、胸腺、脾脏组织形态的影响。结果:与前列腺增生模型组比,益母草总碱160,80,40mg.kg-1可显著降低前列腺增生模型小鼠前列腺指数,前列腺指数分别为(0.53±0.14),(0.51±0.11),(0.64±0.18)mg.g-1;可显著减改善前列腺增生伴发的睾丸、附睾病变;益母草总碱160,80,40 mg.kg-1可显著改善前列腺增生伴发的胸腺、脾脏萎缩,胸腺皮质厚度及淋巴细胞数分别为(24.16±2.22),(26.28±3.20),(26.32±3.31)μm及(60.3±4.5),(68.2±5.2),(53.3±4.2)个,脾小结及淋巴细胞数分别为(14.18±2.32),(16.14±3.04),(29.26±3.52)μm及(17.2±2.0),(15.3±3.1),(28.3±3.4)个。结论:益母草总碱对丙酸睾酮所致的小鼠前列腺增生模型有好的治疗作用。Objective：To explore the effect of total alkaloids in Leonuri Herba（LH） on mice benign prostate hyperplasia（BPH）.Method：Benign prostatic hyperplasia model was established by subcutaneous injecting of testosterone propionate 5 mg·kg-1·d-1 consecutively for 21 d.The mice were randomly divided into 6 groups：160,80,40 mg·kg-1 alkaloids dosage group,Longbishu capsule suspension group,model group.normal control group.Every group was daily given the corresponding drugs for 30 days.The prostate index and histomorphology changes of prostate gland,testicle,epididymis,thymus gland and spleen that were determined.Result： Compared with model group,the total alkaloids in LH at the dosage of 160,80,40 mg·kg-1 could significantly reduce the prostate index of BPH.The prostate index of different groups was（0.53±0.1）.（0.51±0.1）,（0.64±0.18） mg·g-1 respectively.The total alkaloids in LH could significantly improve the pathological changes of testicle and epididymis concomitant with BPH.The total alkaloids in LH at the dosage of 160,80,40 mg·kg-1could significantly improve the atrophy of thymus gland and spleen.The thickness of thymus cortical and the number of lymphocyte was（24.16±2.2）,（26.28±3.20）,（26.32±3.31） μm and（60.3±4.5）,（68.2±5.2）,（53.3±4.2）.The spleniclymphnodules and the number of lymphocyte was respectively（14.18±2.3）,（16.14±3.0）,（29.26±3.52） μm and（17.2±2.0）,（15.3±3.1）,（28.3±3.4）.Conclusion：Total alkaloids in LH has good therapeutic actions on mice BPH.

关 键 词：益母草总碱 丙酸睾酮 前列腺增生 小鼠模型 

分 类 号：R285.5[医药卫生—中药学]