香青兰不同部位提取物对大鼠实验性高脂血症的影响  

Effects of Dracocephalum moldavica on Hyperlipidemia

作　　者：谭梦晖[1] 于波[2] 谷颖敏[3] 祝洁[1] 毕美琼[1] 沈旭华[1] 

机构地区：[1]上海中医药大学中药学院,上海201203 [2]上海中医药大学基础医学院,上海201203 [3]上海中医药大学药物安全评价中心,上海201203

出　　处：《中国实验方剂学杂志》2011年第21期209-213,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市教委科研项目(08cz010)

摘　　要：目的:建立大鼠实验性高脂血症模型,观察香青兰石油醚提取物、乙酸乙酯提取物对高脂血症大鼠血脂水平的影响。方法:采用脂肪乳剂ig制备高脂血症大鼠模型,给药10周后观察香青兰不同提取物对高脂血症大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、超氧化物歧化酶(SOD)、丙二醛(MDA)以及肝组织内SOD,MDA水平的影响;光镜观察大鼠肝组织脂肪变性程度。结果:与模型组比较,香青兰石油醚提取物显著降低高脂血症大鼠血清TG,LDL-C,ALT,AST,MDA(P<0.01或P<0.05),显著升高血清HDL-C,SOD(P<0.01),显著升高肝匀浆SOD(P<0.05),显著降低肝匀浆MDA(P<0.01);香青兰乙酸乙酯提物显著降低高脂血症大鼠血清TC,LDL-C,ALT,AST,MDA(P<0.01),显著升高血清SOD(P<0.05),显著升高肝匀浆SOD(P<0.01),显著降低肝匀浆MDA(P<0.01)。结论:香青兰石油醚与乙酸乙酯提取物能调节高脂血症大鼠脂质代谢紊乱,其调节血脂机制可能与抗氧化有关。Objective：To observe the effect of Dracocephalum moldavica petroleum ether extract and ethyl acetate extract on hyperlipidemia.Method： The rat hyperlipidemia model was established by administration of high rat emulsion.The following indexes were determined： total cholesterol（TC）,triglyceride（TG）,low density ipoprotein-cholesterol（LDL-C）,high density lipoprotein-cholesterol（HDL-C）,malondialdehyde（MDA）,superoxide dismutase（SOD）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,the malondialdehyde（MDA） and superoxide dismutase（SOD） of hepatic tissue after administration of 10 weeks therapy Light microscope was used to observe the steatosis of hepatic tissue in hyperlipidemia rat.Result： Compared with model group,D.moldavica petroleum ether extract could decrease the serum level of TG,LDL-C,ALT,AST,MDA（P〈0.01 or P〈0.05）,increase the serum level of HDL-C,SOD（P〈0.01）,increase the liver homogenate level of SOD（P〈0.05）,and lower the liver homogenate level of MDA（P〈0.01）;Compared with model group,D.moldavica ethyl acetate extract could lower the serum level of TC,LDL-C,ALT,AST,MDA（P〈0.01）,increase the serum level of SOD（P 0.05）,and increase the liver homogenate level of SOD（P〈0.01）,lower the liver homogenate level of MDA（P〈0.01）.Conclusion： D.moldavica extract can regulate lipid metabolism disorders and reduce the incidence of fatty liver and its modulation may be related to its antioxidant capacity.

关 键 词：香青兰石油醚提取物 香青兰乙酸乙酯提取物 高脂血症 大鼠 抗氧化 

分 类 号：R285.5[医药卫生—中药学]