中药对血管平滑肌细胞的影响  

Effect of Traditional Chinese Medicine on Vascular Smooth Muscle Cells

作　　者：张海燕[1,2] 邬伟魁[1] 贺娅[1] 宋伟[1] 李芳[1] 郑琴[1] 杨明[1,3] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,南昌330004 [2]西南交通大学材料先进技术教育部重点实验室,成都610003 [3]成都中医药大学,成都611137

出　　处：《中国实验方剂学杂志》2011年第21期273-278,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：中医药行业科研专项项目(200708006);"十一五"重大新药创制重大专项(2009ZX09103-393;2009ZX09310-005)

摘　　要：整理和分析中药对血管平滑肌细胞(vascular smooth muscle cells,VSMC)的影响。血管疾病对患者的危害较大,VSMC的表型转化、过度增殖和迁移是动脉粥样硬化(atherosclerosis,AS)、血管成形术后再狭窄和高血压等血管疾病形成的主要环节,故研究中药对VSMC的调节作用对血管疾病的防治意义重大。对中药促使VSMC表型转化、抑制细胞异常增殖和迁移及其分子机制、基础动物实验等方面的研究文献报道进行总结,并对血管平滑肌细胞与内皮细胞、内皮祖细胞及巨噬细胞之间的关系进行分析。结果表明,中药在AS等血管疾病的防治中具有良好的效果,但由于其成分复杂,作用机制难以明确、质量难以控制及毒副作用限制了其在临床中的应用,故结合中药血清药理学等方法,加强中药活性单体化合物对VSMC调节作用的深入研究或将给血管疾病的防治带来新的希望。Literatures about the effect of traditional Chinese medicine on vascular smooth muscle cells（VSMC） have been analyzed.Atherosclerosis（AS） has big damage on humans.Phenotypic,excessive proliferation and migration of vascular smooth muscle cells are the key to pathogenic mechanism of diseases,so studying the effect of traditional Chinese medicine on VSMC is significant on prevention of atherosclerosis.This paper mainly reviews promoting phenotypic of traditional Chinese medicine on vsmc,inhibiting excessive proliferation and migration and its mechanism,basic animal experiment,also discusses the relationship of VSMC with endothelial cells and endothelial progenitor cells and macrophage.Research has showed that traditional Chinese medicine has good effect on vascular diseases,because of its complicated composition,difficult to definite its mechanism and to control its quality,and its side effect which limit its application in clinic.Therefore,combing with serum pharmacology and strengthening studying on active monomer compounds of traditional Chinese medicine may bring new hopes for AS.

关 键 词：血管疾病 血管平滑肌细胞 动脉粥样硬化 

分 类 号：R285[医药卫生—中药学]