通关藤的化学成分与药理活性研究进展  

Progress on Chemical and Pharmacological Studies of Marsdenia tenacissima

作　　者：于绍帅[1,2] 陈明苍[2] 李志雄[2] 季宇彬[1] 吴斌[2] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心药物研究所博士后科研工作站,哈尔滨150076 [2]中国科学院上海药物研究所,上海201203

出　　处：《中国实验方剂学杂志》2011年第21期279-283,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重大新药创制项目(2009ZX09308-005)

摘　　要：目的:对萝蘑科牛奶菜属植物通关藤的化学成分及其药理作用研究的内容进行文献整理和分析。方法:通过中国科学院上海药物研究所图书数据库平台查阅近5年国内外有关通关藤、通光藤、乌骨藤的药理作用与化学成分的报道。结果:通关藤的化学成分较为复杂,研究主要集中在C21甾体苷上,药理活性的研究主要集中在抗肿瘤的作用上,现在临床上已有多种以通关藤为主要原料的制剂用于各种癌症的治疗,但是缺少其具体起效的成分研究及其作用机制的研究,因此,对其化学成分及药效学基础的研究必不可少。结论:近年来对通关藤抗肿瘤的作用研究较多,还需加强对通关藤其他方面的药理作用的研究,特别是其古医书记载对呼吸系统的作用,有必要进行进一步研究。Objective：The chemical compositions and pharmacological activities of the Marsdenia tenacissima were reviewed and analyzied.Method： We search data on chemical compositions and pharmacological effects of M.tenacissima in recent years by the CAS Shanghai institute of materia database platform.Result： The chemical constituents of M.tenacissima is more complex,so the current research focuses on C21 steroidal glycosides.Its pharmacological research is now mainly in their antitumor effect.Now it has a variety of clinical drug which used M.tenacissima as main raw material for treatment of various cancers.But it still lack study which is the specific effective constituents of M.tenacissima and what is the mechanism,therefore,the chemical components and pharmacodynamics of M.tenacissima must be study.Conclusion： In recent years,study on anti-tumor effect of M.tenacissima has more reports,other pharmacological research,particularly the actions on the respiratory system,need to be strengthened,and this paper can provide reference for further research and development.

关 键 词：通关藤 通光藤 乌骨藤 化学成分 药理 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]