糖化血红蛋白与颈动脉超声在冠状动脉狭窄病变中的应用观察  

Application of glycosylated hemoglobin and carotid artery ultrasound in patients with coronary artery stenosis

作　　者：杨剑峰[1] 梁毅[1] 张鸿举[1] 

机构地区：[1]徐州市第一人民医院心内科,江苏徐州221002

出　　处：《徐州医学院学报》2011年第10期687-689,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的观察糖化血红蛋白（HbAlC）与颈动脉超声检查在冠状动脉狭窄病变患者中的应用。方法入选患者按照冠状动脉造影结果分为2组：A组，观察组，冠状动脉主要分支的管腔狭窄≥50％，A组患者再根据冠状动脉狭窄病变累及血管支数分为单支、双支和三支冠状动脉病变亚组；B组，对照组，冠状动脉主要分支的管腔狭窄〈50％。分别对各组的HbAlC、颈动脉超声检查结果及合并糖尿病资料进行比较，并进行差异性分析。结果A组患者HbAlc明显增高，颈动脉内膜中层增厚明显，斑块形成及合并糖尿病患者较多，与B组比较差异有统计学意义（P〈0．01）；A组患者冠状动脉狭窄病变累及支数越多，相对应HbAlc数值越高，内膜中层增厚患者越多，双支、三支亚组与B组比较差异有统计学意义（P〈0．05）；对于斑块形成及合并糖尿病，单支病变亚组患者与B组比较差异无统计学意义（P〉0．05），而双支及三支病变亚组患者与B组比较差异有统计学意义（P〈0．05）。结论HbAlC联合颈动脉超声检查能更好地提示冠状动脉狭窄病变及程度，对指导临床及时采取干预治疗措施具有重要意义。Objective To observe the application of glycosylated hemoglobin （HbAlc） and Carotid artery ultrasound in patients with coronary artery stenosis. Methods Enrolled patients were divided into two groups according to coronary angiography. Group A （ observation group） , the main branches of coronary artery stenosis were ≥50% ; Group B （control group）, the main branches of coronary artery stenosis were 〈 50%. Group A was further devided into single, double, and three vessel disease subgroups based on the number of coronary arteries involved. HbAlc, carotid artery ultrasound, and diabetes mellitus data in these groups were compared and differences between the various parameters were analyzed. Results Compared with group B, the level of HbAlc was significantly increased in group A, with more obvious carotid artery intima - media thickening and plaque formation and more patients with diabetes mellitus in group A （ P 〈 0.01 ）. For group A patients, the more the number of stenotic coronary arteries involved, the higher the corresponding level of HbAle, and more patients with intima -media thickening. There were statistically significant differences between double and three vessel disease subgroups and group B （P 〈 0.05）. For plaque formation and cases combined with diabetes mellitus, there were no significant differences between single vessel disease subgroup and group B （ P 〉 0.05 ） , while there were signifieat differences between double and three vessel disease subgroups and group B （P 〈 0.05 ） . Conclusion HbAl c levels combined with carotid ultrasond examination can be a better way to suggest the degree of coronary artery disease and is considered of important clinical significance in clinical treatment and timely intervention for coronary artery stenosis.

关 键 词：糖化血红蛋白 颈动脉超声 冠状动脉狭窄 

分 类 号：R543[医药卫生—心血管疾病] R587.1[医药卫生—内科学]