兰索拉唑的电化学分析  

The study on electrochemical analysis of lansoprazole in drug

作　　者：陈立新[1] 李心恬[2] 方红[2] 周原[1] 

机构地区：[1]湖南工程学院化学化工学院,湘潭411104 [2]深圳出入境检验检疫局工业品中心,深圳518045

出　　处：《分析试验室》2011年第11期74-77,共4页Chinese Journal of Analysis Laboratory

基　　金：湖南省教育厅科研基金(10C0555)资助

摘　　要：在NaH2PO4-Na2HPO4溶液中,用循环伏安法、差分脉冲伏安法(DSV)和方波伏安法(SWV)在玻碳电极(GCE)上对兰索拉唑进行了电化学研究,发现兰索拉唑在-1.3伏左右有一个明显的阴极还原峰,考察了不同底液及pH、扫描速度、富集时间和静止时间的影响,DSV法线性范围为6.0×10-6～1.0×10-3 mol/L,检出限为5.0×10-7 mol/L;SWV法线性范围为2.0×10-6～2.0×10-3 mol/L,检出限为1.0×10-7 mol/L。并对兰索拉唑的电极反应机理进行了探讨,该方法可用于实际药品测定。Cyclic voltammetry, differential-pulse stripping voltammetry, and square wave voltammetry were used to investigate the electrochemical behavior of lansoprazole at a glassy carbon electrode and a new method for the detection of lansoprazole was established. The lansoprazole showed a sensitive reduction peak at -1.3 V （vs. SCE） using cyclic voltammetry in a buffer solution of NaH2PO4-Na2HPO4. The impact of buffer solution, pH, accumulation time and scan rate were discussed. The peak current was linear to the concentration of lansoprazole ranging from 6. 0 ×10^-6 to 1.0×10^-3 mol/L with a detection limit of 5.0×10^-7 mol/L by DSV, and ranging from 2. 0 ×10^-6 to 2.0 ×10^ -3 mol/L with a detection limit of 1.0 ×10^-7 mol/L by SWV. The determination of lansoprazole has been performed and the possible mechanism for the electrode process has also been proposed.

关 键 词：循环伏安法 差分脉冲伏安法 方波伏安法 玻碳电极 兰索拉唑 

分 类 号：O657.1[理学—分析化学]