pH值对诺氟沙星正辛醇-水分配系数的影响  

The pH-dependence of n-octanol/water partition coefficient of norfloxacin

作　　者：李献文[1] 雷月香[1] 

机构地区：[1]闽江学院化学与化学工程系,福建福州350108

出　　处：《闽江学院学报》2011年第5期91-93,共3页Journal of Minjiang University

摘　　要：以正辛醇-水为模拟系统,采用摇瓶法-紫外分光光度法测定分配平衡后水相中诺氟沙星的浓度,由此计算诺氟沙星的正辛醇-水分配系数,得出该系数受pH的影响,pH=1.22时分配系数最小,pH=7.4时分配系数最大.从而得到诺氟沙星弱碱环境的脂溶性大于酸性环境的结论.A shake flask-ultraviolet spectrophotometry method was used.The concentration of norfloxacin in water after the establishment of partition equilibrium was evaluated.The logPOW of norfloxacin was pH-dependent.The minimum logPOW value was observed at pH=1.22 and the maximum at pH=7.4.The fat solubility of norfloxacin is higher in weak alkali environment than in acidic environment.

关 键 词：诺氟沙星 油水分配系 PH 

分 类 号：O657.32[理学—分析化学]