2型糖尿病肾病患者高半胱氨酸、C反应蛋白联合检测的临床意义  

The Clinical Significance of High Homocysteine and C-reactive Protein Combined Detection in Type 2 Diabetic Patients

作　　者：何云霄[1] 

机构地区：[1]浙江省天台县中医院检验科,浙江天台317200

出　　处：《中国现代医生》2011年第31期82-83,共2页China Modern Doctor

摘　　要：目的探讨2型糖尿病肾病患者高半胱氨酸、C反应蛋白联合检测的临床意义。方法检测36例2型糖尿病肾病患者高半胱氨酸、C反应蛋白水平,并选择同期行健康体检者作为对照组进行比较分析。结果 DN组Hcy、CRP、UAE水平明显高于对照组,两组比较差异有统计学意义(P<0.05或P<0.01)。经直线相关分析显示,血清Hcy、CRP与MAU呈显著正相关(r=0.721、0.542,P<0.01)。结论血清Hcy、CRP浓度在DN患者中显著升高,且与UAE呈正相关,它们与DN发生发展有关。对糖尿病并发DN的早期诊断、病情发展的分析和监测有一定的临床意义,对糖尿病未来风险的预见及临床治疗的有效性评估提供了一定的参考价值。Objective To investigate the clinical significance of high homocysteine and C-reactive protein combined detection in type 2 diabetic patients. Methods Thirty six cases of type 2 diabetic patients with high homocysteine, C reactive protein level, and the same row selected as the healthy control group were analyzed. Results DN group of Hcy, CRP, UAE levels were significantly higher, and the differences were statistically significant （P 〈 0.05 or P 〈 0.01）. The linear correlation analysis showed that serum Hcy, CRP and MAU were significantly correlated （r=0.721, 0.542, P 〈 0.01）. Conclusion Serum Hcy, CRP concentrations are significantly higher in DN patients, and are positively correlated with the UAE, concerned with the development of DN. They have clinical significance for the early diagnosis of diabetes mellitus combined with DN, analysis and monitoring of progression of the disease, and have a certain reference value for the expected future risk of diabetes and clinical evaluation of the effectiveness.

关 键 词：2型糖尿病肾病 高半胱氨酸 C反应蛋白 联合检测 

分 类 号：R587.2[医药卫生—内分泌]