不同浓度医用臭氧联合玻璃酸钠治疗骨性膝关节炎的临床研究  

Effect of medical ozone combined with sodium hyaluronate on the knee osteoarthritis

作　　者：蒋宗滨[1] 方懿[1] 何睿林[1] 周增华[1] 许圣荣[1] 黄剑峰[1] 

机构地区：[1]广西医科大学第一附属医院西院麻醉科,南宁市530021

出　　处：《临床麻醉学杂志》2011年第10期998-1000,共3页Journal of Clinical Anesthesiology

基　　金：广西教育厅科研项目(桂教200911LX26);广西卫生厅科研课题(Z2007075)

摘　　要：目的研究医用臭氧联合玻璃酸钠治疗骨性膝关节炎(KOA)的治疗用量。方法骨性膝关节炎患者48例,共80膝,随机分为四组,每组20膝。分别给予臭氧(A组20μg/ml、B组30μg/ml、C组40μg/ml)15 ml,每周1次,连续3周和玻璃酸钠行患膝关节腔内注射2 ml,每周一次,连续3周,对照组(D组)行玻璃酸钠膝关节腔内注射,每次2 ml,每周一次,连续5周。观察A、B、C三组治疗前后患者VAS评分、关节活动度(ROM)、Lysholm关节功能评分变化情况。结果臭氧治疗后第1周C组VAS评分低于A、B组(P<0.05);臭氧治疗后第3周C组Lysholm关节功能评分优于A、B组(P<0.05);治疗后C组患者关节肿胀、疼痛和跛行评分高于D组(P<0.05);总优良率C组高于D组(P<0.05)。结论 40μg/ml的臭氧联合玻璃酸钠可以缓解骨性膝关节炎疼痛,改善关节功能。Objective To explore the effect of medical ozone combined with sodium hyaluronate on the knee osteoarthritis. Methods Eighty osteoarthritis knees were randomly divided into 4 groups with 20 each. The cavum articulares were injected with medical ozone 15 ml once a week （group A 20 μg/ml ozone, group B 30 μg/ml ozone, group C 40 μg/ml ozone） and sodium hyaluronate 2 ml once a week for 3 weeks. Control group （group D） received sodium hyaluronate 2 ml once a week for 5 weeks. The VAS score, range of motion （ROM） and Lysholm knee score were observed and compared before and after treatment. Results The VAS score in group C decreased more significantly than those in group A and B after 1 week treatment （ P 〈 0. 05 ）. After 3 weeks of treatment, the improvement of Lysholm knee score in group C was more evident than those in group A and B （P〈 0.05）. The score of joint swelling,pain,and lameness in group C were significantly evident than that in group D（P〈0.05）. The total efficacy in group C was higher than that in group D（P〈0.05）. Conclusion Ozone 40 μg/ml combined with sodium hyaluronate can relieve knee osteoarthritis pain and improve joint function.

关 键 词：臭氧 玻璃酸钠 膝骨性关节炎 治疗 

分 类 号：R684.3[医药卫生—骨科学]