肾小球系膜细胞与氧化应激  

Glomerular mesangial cell and oxidative stress

作　　者：孙文佳[1] 叶山东[1] 

机构地区：[1]安徽医科大学附属省立医院内分泌科,合肥230001

出　　处：《国际病理科学与临床杂志》2011年第5期448-452,共5页Journal of International Pathology and Clinical Medicine

摘　　要：肾小球系膜细胞是最活跃的细胞固有成分,其在多种因素如高糖、血管紧张素-II、醛固酮、机械牵拉、炎症反应、脂质沉积等刺激下表现为氧化应激(活性氧类产生过多和清除减少),促进肾小球硬化(包括糖尿病肾病)的发生和发展。干预治疗如噻唑烷二酮、血管紧张素转换酶抑制剂和血管紧张素Ⅱ受体阻滞剂、醛固酮受体拮抗剂、他汀类药物、抗氧化剂等均可减少系膜细胞氧化应激。Mesangial cell is one of the most active natural cells in renal tissues.Many factors such as high glucose,angiotensin II,aldosterone,mechanical stress,inflammation,and lipid deposition are involved in oxidative stress of mesangial cells,which promote the occurrence and development of glomerular sclerosis including diabetic nephropathy.Thiazolidinediones,angiotensin converting enzyme inhibitors,and angiotensin-II receptor blockers,adosterone receptor blockers,statins drugs,and antioxidants can alleviate the oxidative stress of mesangial cell.

关 键 词：肾小球硬化 糖尿病肾病 系膜细胞 氧化应激 

分 类 号：R692.6[医药卫生—泌尿科学]