中药双黄清胆颗粒对微创保胆术后患者胃动素、生长抑素与胆囊收缩素水平变化的临床研究  

Clinical research of traditional Chinese medicine-fanshi granules on the level of motilin, somatostatin and cholecystokinin after microinvasive gallbladder-protected lithotomy

作　　者：葛长青[1] 李全福[1] 王丽璞[2] 牛建海[2] 刘建辉[1] 邵青龙[1] 郭超[1] 钟永刚[1] 许旭[1] 

机构地区：[1]卫生部内镜与微创专业技术培训基地(河北省保定市第二医院肝胆外科),河北保定071051 [2]河北省保定市第一中医院,河北保定071000

出　　处：《中国内镜杂志》2011年第10期1036-1038,1042,共4页China Journal of Endoscopy

摘　　要：目的观察内镜微创保胆取石术后中药双黄清胆颗粒不同时间血浆胃动素(MTL)、生长抑素(SS)与胆囊收缩素(CCK)水平的变化,探讨其对胆囊结石激素因素的影响,评价中药预防结石复发的临床作用。方法随机选择168例通过腹腔镜联合胆道镜保胆术患者,采用放射免疫等方法测定患者术前、术后15、30、60和90d外周血胃动素、生长抑素与胆囊收缩素水平。结果 168例内镜保胆均获成功,4～6d痊愈出院。术后15d胃动素、胆囊收缩素水平低于术前、生长抑素高于术前;术后30d血浆胃动素、生长抑素与胆囊收缩素水平与术前比较,差异均无显著性。术后60和90d外周血胃动素、胆囊收缩素水平高于术前、生长抑素低于术前,差异均有显著性(P<0.05)。结论内镜保胆取石术后结合双黄清胆颗粒治疗,可影响血浆胃动素、生长抑素与胆囊收缩素水平的波动,改变胆汁成分,增加胆囊收缩功能。【Objective】To watch the level of motilin, somatostatin and cholecystokinin in serum at different time phages after given Fangshi granules after endoscopic invasive cholecystolithotomy with gallbladder preserved. To investigate the affect of hormonal influences on gallstone, and to evaluate traditional Chinese medicine to prevent the relapse of cholelithiasis.【Methods】Randomly selected 168 cases of cholecystolithiasis who were treated by laparoscope and choledochoscope preservation of gallbladder. Radioimmunoassay was used to test the level of motilin, somatostatin and cholecystokinin in serum during different time phases before surgery and after surgery for 15 days, 30 days, 60 days and 90 days. 【Results】All the operations of microinvasive gallbladder-protected lithotomy for 168patients were successful. No serious complication appeared. All the patients were recovered and discharged from hospital after 4 to 6 days. The level of motilin and somatostatin after surgery for 15 days were lower than that of before surgery, and the level of cholecystokinin was higher than that of before surgery. But no significant difference was found between the two groups. Those indexes for 30 days were close between the two groups of after surgery and before surgery. The level of motilin and somatostatin after surgery for 60days and 90days were higher that of before surgery, and the level of cholecystokinin was lower that of before surgery. Significant difference was found between the two groups （P〈0.05）.【Conclusion】Application of Fanshi granules for patients received microinvasive gallbladder-protected lithotomy can affect the level of motilin, somatostatin and cholecystokinin in serum, change the composition of bile, and enhance the contraction function of gallbladder.

关 键 词：素与胆囊收缩素水平的波动 改变胆汁成分 增加胆囊收缩功能关键词:内镜保胆 双黄清胆颗粒 胃肠激素 

分 类 号：R657.4[医药卫生—外科学]