重组人白细胞介素-11治疗脓毒症相关血小板减少症的疗效观察  

Curative effect of recombinant human interleukin-11 in the treatment of sepsis-related thrombocytopenia

作　　者：宗丹丹[1] 曹书华[2] 王勇强[2] 

机构地区：[1]天津医科大学一中心临床学院,300070 [2]天津市第一中心医院ICU,300192

出　　处：《中国急救医学》2011年第11期975-978,共4页Chinese Journal of Critical Care Medicine

摘　　要：目的 观察重组人白细胞介素-11治疗脓毒症相关血小板减少症患者的疗效.方法 以入住天津市第一中心医院ICU并发生血小板减少的54例脓毒症患者为研究对象,分为治疗组和对照组.两组患者均接受积极抗感染、对症支持治疗,治疗组自血小板下降第1天予以皮下注射重组人白细胞介素-11 1.5 mg/kg,每日1次,疗程7~14 d,当血小板≥100×109/L时停药.结果 治疗组在第7天及第14天血小板计数显著高于对照组（P〈0.05）,血小板输注率显著低于对照组（P〈0.05）;治疗组血小板恢复到〉50×109/L及〉100×109/L所需的时间较对照组显著缩短（P〈0.05）;治疗组在第7天及第14天APACHEⅡ评分显著低于对照组（P〈0.05）.结论 脓毒症相关血小板减少症患者在积极抗感染治疗的同时加用重组人白细胞介素-11,可加速血小板数量的恢复,缩短血小板减少的持续时间,减少血小板输注,改善预后,而且重组人白细胞介素-11的不良反应轻微,可以安全有效地用于脓毒症相关血小板减少症.Objective To observe the efficacy of recombinant human interleukin - 11 in the treatment of sepsis - related thrombocytopenia. Methods Fifty - four septic patients who developed thrombocytopenia in ICU were divided into treatment group and control group. All the patients received active antibiotics, symptomatic and supportive treatments. From the day platelet decreased, patients in the treatment group received subcutaneous injection of recombinant human interleukin - 11 （ 1.5 mg/kg, every day） for 7 to 14 days. The injection was discontinued when the platelet ≥ 100 ×109/L. Results Compare with the control group, the platelet count was significantly higher in 7th day and 14th day （ P 〈 0.05）, platelet transfusion was significantly less （ P 〈 0.05 ）, the time of platelet recovery to 〉 50 x 109/L and 〉 100 ×109/L was significantly shorter （P 〈0.05） , and APACHE Ⅱ score in 7th and 14th day was significantly lower （ P 〈 0.05 ） in the treatment group. Conclusion Adding recombinant human interleukin - 11 to the patients with sepsis - related thrombocytopenia can accelerate the recovery of platelet count, shorten the duration of thrombocytopenia, reduce platelet transfusion, and improve the prognosis. Recombinant human interleukin - 11 has mild adverse reactions, it can be used in sepsis - related thrombocytopenia safely and effectively.

关 键 词：重组人白细胞介素-11 脓毒症 血小板减少症 

分 类 号：R973[医药卫生—药品]