中等取代度的羟丙基-β-环糊精对依托泊苷的包埋特性分析  

Analysis of complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on etoposide

作　　者：孙鹤文[1] 韩静[1] 张玥[1] 郭小然[1] 

机构地区：[1]沈阳药科大学制药工程学院,沈阳110016

出　　处：《药物分析杂志》2011年第11期2103-2107,共5页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:研究取代度为6.7的羟丙基-β-环糊精对难溶性药物依托泊苷的包埋特性。方法:采用红外分光光度法、差示扫描量热法、X-射线衍射法对包合物进行了研究。结果:羟丙基-β-环糊精与依托泊苷形成了1∶1的包合物,提高依托泊苷在水中的溶解度约75.1倍。结论:本实验的研究内容在提高药物的溶解度、稳定性和生物利用度等方面有广阔前景。Objecfive：Hydroxypropyl-β- cyclodextrins of substituted degree of 6. 7 was investigated the complex forming capability by etoposide. Method： The inclusion complex was generated by IR, DSC and XRD. Results： Etoposide was formed a 1 ： 1 molar ratio inclusion complex with hydroxypropyl -β- cyelodextrins and improved solubility about 75.1 times. Conclusion： The experimental research has broad prospect on improving drug solubility, stability, bioavailability and so on.

关 键 词：抗肿瘤药 依托泊苷 足叶乙苷 羟丙基-Β-环糊精 合成工艺优化 包埋 增溶效果 红外分光光度法 差示扫描量热 法 X-射线衍射法 

分 类 号：R917[医药卫生—药物分析学]