振动光谱法研究灯盏花素固体分散体的分散特性  

Study on the dispersivity of breviscapine solid dispersion by vibrational spectrometry

作　　者：王玮[1] 李晓曼[1] 席欣欣[1] 曹凯[1] 程黎[1] 

机构地区：[1]河南大学药学院,河南开封475004

出　　处：《药物分析杂志》2011年第11期2118-2120,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:用拉曼和红外光谱法研究灯盏花素固体分散体的分散性,以期获得一种新的简单易行的检查固体分散体分散性的方法。方法:用溶剂法制备灯盏花素固体分散体,用显微共焦拉曼光谱仪、傅里叶变换红外光谱仪和X射线衍射仪分别采集灯盏花素、乙基纤维素(EC)、灯盏花素:EC(1∶3)的物理混合物(PM)以及灯盏花素固体分散体(SDbre)的拉曼图谱、红外图谱和X射线衍射图谱并进行对比分析。结果:灯盏花素以分子状态包埋在EC的网状骨架中,三种方法得到一致的结果。结论:拉曼光谱法快速、直接、对样品无损伤,是一种新的理想的检查固体分散体分散性的方法。Objective：To study the dispersivity of breviscapine solid dispersion by Raman spectrometry and infrared spectrometry in order to obtain a new and simple method in examining the dispersivity of solid dispersion. Methods：Breviscapine solid dispersion was prepared by solvent method. The Raman spectra,infrared spectra and XRD spectra of breviscapine, ethyl cellulose （EC）, physical mixture, solid dispersion were acquired by Raman and Fourier transform infrared spectrometers and X -ray powder diffractometry. And the spectra were compared with each other in order to find out the differences between breviscapine solid dispersion and other materials. Results：The three methods obtained the same result- breviscapine was dispersed in the reticular framework of EC in the state of molecule. Conclusions：Raman spectrometry which is fast,direct and non -destructive is an ideal method in examining the dispersivity of solid dispersion.

关 键 词：心血管用药 缓释制剂 黄酮类灯盏花素 固体分散体 拉曼光谱法 红外光谱法 分散机制 包埋状态 

分 类 号：R917[医药卫生—药物分析学]