女性抑郁症患者尾状核和杏仁体磁共振研究  

An MRI study of the caudate nucleus and amygdala volumes in female major depression disorder

作　　者：陈国中[1] 宋慧慧[2] 蔡晶[2] 李阳[3] 马丽[1] 李月峰[2] 徐金[1] 李国海[3] 王冬青[2] 姜平[1] 

机构地区：[1]江苏大学基础医学与医学技术学院脑功能与影像研究室,镇江212013 [2]江苏大学附属医院影像科 [3]江苏大学附属四院精神科

出　　处：《临床精神医学杂志》2011年第5期302-304,共3页Journal of Clinical Psychiatry

基　　金：江苏省卫生厅科研基金(H200951)

摘　　要：目的:探讨女性抑郁症患者的尾状核和杏仁体的体积变化。方法:采用3.0磁共振,分别测量抑郁症患者(30例,抑郁组)及对照组(30名)的尾状核和杏仁体的体积。结果:抑郁症组尾状核体积左右侧分别为(4349±517.5)mm3,(4208±394.3)mm3;对照组组尾状核体积左右侧为(5086±449.3)mm3,(5092±350.2)mm3,两组相比较经t检验,P<0.01有统计学意义。抑郁症组左右侧杏仁体体积为(2059±218)mm3,(2005±227)mm3,对照组左右侧杏仁体体积为(1854±278)mm3,(1820±216)mm3,抑郁组与正常组的杏仁体体积相比较,杏仁体体积明显大于对照组(P<0.05)。抑郁症杏仁体层数为(15.4±6.2);正常组杏仁体层数为(16.7±7.1)。结论:女性抑郁症初发患者可能存在尾状核缩小和杏仁体反应性增大的改变。Objective：To study the characteristics of the caudate nucleus and the amygdala volume change in female depressed patients.Method：3.0 T magnetic resonance imaging was used to measure the volume of the caudate nucleus and the amygdala in 30 patients with depression and 30 control.Results：the volume of the caudate nucleus in depression group：left was（4349±517.5）mm3,right was（4208±394.3）mm3;the volume of the caudate nucleus in control group：left was（5086±449.3）mm3,right was（5092±350.2）mm3.There was significant difference between the two groups;the volume of the amygdala in depression group：left was（2059±218） mm3,right was（2005±227） mm3;the volume of the amygdala in control group：left was（1854±278） mm3,right was（1820±216） mm3,volumes in depression group were obviously lager than those in control group（P〈0.05）.The number of slices of amygdala in depression group was（15.4±6.2）,the number of slices of amygdala in control group was（16.7±7.1）.Conclusion：The result indicated that in early episode of depression the volumes of caudate nucleus decreased and the volumes of amygdala patients showed increased reactively.

关 键 词：抑郁症 尾状核 杏仁体 磁共振成像 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]