不同时间给予比索洛尔治疗高血压患者的24h动态血压变化和安全性  

Change of 24 h ambulatory blood pressure and safety in patients with hypertension after different dosage regimen of bisoprolol

作　　者：王少华[1] 王红程[1] 刘华强[1] 闫美兴[1] 孙晓蕾[2] 

机构地区：[1]青岛市市立医院药学部,山东青岛266011 [2]青岛大学医学院,山东青岛266021

出　　处：《中国医院药学杂志》2011年第21期1790-1793,共4页Chinese Journal of Hospital Pharmacy

基　　金：山东省卫生厅立项课题(编号:2007hw005)

摘　　要：目的:考察不同时间给予比索洛尔治疗非杓型高血压的疗效和安全性。方法:入选60例非杓型轻中度高血压患者,随机分为早晨给药组(08:00)和夜间给药组(20:00),分别给药2.5～10 mg,对治疗8周前后的24 h动态血压、实验室指标和不良事件发生情况进行分析评价。结果:清晨给药和夜间给药均能降低非杓型高血压患者的血压(P<0.05),夜间给药组对患者06:00-09:00及21:00-24:00的血压控制幅度较早晨服药组明显增大。2组对患者的血常规和肝肾功指标无明显影响,研究过程中共发生3例不良事件,经统计2组间不良事件的发生率比较,差异无显著性。结论:比索洛尔早晨给药和夜间给药均能安全有效的降压,夜间服药更有利于控制患者的夜间和清晨血压。OBJECTIVE To investigate the efficacy and safety in patients with non-dipper type hypertension after different dosage regimen of bisoprolol treatment. METHODS The patients were randomly divided into two parallel groups. All patients were treated with bisoprolol. The first group took bisoprolol at eight o＇clock once-daily between 2.5 mg and 10 mg. The second group took bisoprolol at twenty o＇clock once-daily between 2. 5 mg and 10 mg. The efficiency of the 8 weeks treatment and the change of the 24 hours blood pressure, laboratory parameters and adverse events analysis and evaluation of the situation were detected. RESULTS The blood pressures of the patients in both groups decreased（P〈0. 05）, but taking bisoprolol at night of the second group had a better efficacy than that in the first group. In the second group patients taking hisoprolol at night, their （16 ： 00 - 09 ： 00 and 21 00 - 24 ： 00 of blood pressure control rate was significantly increased as compared with the morning medication group. The blood and liver and kidney functions of the two groups of patients showed no significant adverse reactions. The adverse events occurred in 3 cases, the statistics of the incidence of adverse events between the two groups was no significant difference. CONCLUSION Both dosage regimens of treatment can control the blood pressure with good safety and efficacy, hut taking drug at twenty o＇clock was better for the non-dippers hypertension and the diurnal rhythm of blood pressure than taking at eight o＇clock.

关 键 词：比索洛尔 非杓型高血压 疗效 安全性 

分 类 号：R972.4[医药卫生—药品]