无高危因素的三种清洁手术预防用药  

Preventive medication in three kinds of clean surgery without high-risk factors

作　　者：庞晓军[1] 赖广平[1] 邓忠南[1] 叶开华[1] 朱其海[1] 

机构地区：[1]钦州市第二人民医院,广西钦州535000

出　　处：《中国医院药学杂志》2011年第21期1793-1794,共2页Chinese Journal of Hospital Pharmacy

基　　金：钦州市科技局立项课题(编号:20094108)

摘　　要：目的:探讨无高危因素的三种清洁手术是否需要预防用药。方法:选择2009年7月-2011年4月在我院住院需进行乳腺、疝气、甲状腺手术无高危因素患者63例,采用随机数字表随机分为两组,试验组在严格的无菌操作条件下进行手术治疗,仅采用聚维酮溶液消毒,对照组手术前30 min给予五水头孢唑林1～2 g,静脉滴注,两组遵从严格的无菌操作要求进行手术,对比两组术后体温恢复正常时间、切口感染率、住院药费及术后住院时间。结果:两组术后体温恢复时间、切口感染率和术后住院时间无统计学差异,试验组住院药费明显低于对照组。结论:无菌手术切口感染与预防性使用抗菌药物无关,无高危因素清洁手术我们不推荐常规给予抗菌药物预防感染。OBJECTIVE To discuss the topic of preventive medication in three kinds of clean surgery without high-risk factors. METHODS 63 cases of hospitalized patients were chosen in July, 2009 - April, 2011 for carrying on breast, hernia and thyroid operation without high-risk factors in our hospital. By using table of random number, the patients were divided into two groups stochastically. The patients of experimental group were treated with the surgery under the strict asepsis operating condition, only pvp-iodine solution was used for disinfection. In the control group 30min before surgery the patients were given with cefazolin sodium pentahydrate 1 - 2 g, iv drip. Both groups complied with the strict asepsis operation to carry on the sur- gery. The time of body temperature to restore to the normal level, the infection rate of incisional wound, the charges in hospital for medicine and the hospitalized days were compared between the two groups. RESULTS There was no statistic difference in the time of body temperature to restore to the normal level, the infection rate of incisional wound and the hospitalized days between the two groups. The charges in hospital for medicine of the experimental group were lower than that of the control group obviously. CONCLUSION The preventive use of antibiotics has nothing to do for germ-free surgery infection of incisional wound, We do not recommend conventionally to give the antibiotics to prevent infection in clean surgery without high-risk factors.

关 键 词：无高危因素 清洁手术 预防用药 切口感染 

分 类 号：R969[医药卫生—药理学]