妊娠肝内胆汁淤积症高危因素的Logistic回归分析  

LOGISTIC REGRESSION ANALYSIS ON RISK FACTORS OF INTRAHEPATIC CHOLESTASIS OF PREGNANCY

作　　者：陈忠[1] 许建娟[1] 冯一中[2] 

机构地区：[1]无锡市妇幼保健院妇产科,无锡214002 [2]苏州大学医学部病理学系

出　　处：《现代预防医学》2011年第21期4376-4377,4380,共3页Modern Preventive Medicine

摘　　要：[目的]探讨妊娠肝内胆汁淤积症（ICP）高危因素,为ICP的临床治疗提供理论依据。[方法]选择2009年1月~2010年12月某院住院分娩ICP患者82例（ICP组）和正常晚期妊娠妇女86例（对照组）为研究对象,应用回归性对照研究对ICP高危因素进行分析。[结果]与对照组相比较,体内雌激素水平、机体免疫失调、遗传因素、微量元素硒的含量与ICP显著相关,差异有统计学意义（P﹤0.05）。多因素回归分析结果显示体内雌激素水平、机体免疫失调、微量元素硒的含量为ICP高危因素。[结论]体内雌激素水平、机体免疫失调、微量元素硒的含量为ICP高危因素,对有ICP的产妇积极采取措施,避免产后母儿并发症的发生。[Objective]To discuss the risk factors of intrahepatic cholestasis of pregnancy,and provide the theoretical bases for clinical treatment.[Methods]From 2009 January-2010 June,intrahepatic cholestasis of pregnancy（ICP）in 82 patients（ICP group）and 86 cases of normal late pregnant women（control group）were selected as the research subjects,the risk factors of intrahepatic cholestasis of pregnancy was analyzed with regression of case-control study.[Results]Compared with the control group,estrogen levels,immune disorders,genetic factors,selenium content and intrahepatic cholestasis of pregnancy were significantly associated,the difference was statistically significant（P﹤0.05）.Multivariate regression analysis showed that estrogen levels,immune disorders,selenium content were the risk factors of intrahepatic cholestasis of pregnancy.[Conclusion]Estrogen levels,immune disorders,selenium content are the risk factors of intrahepatic cholestasis of pregnancy,it should take active measures for parturients with intrahepatic cholestasis of pregnancy to prevent post-natal mothers＇ and children＇s complications.

关 键 词：妊娠肝内胆汁淤积症 危险因素 LOGISTIC回归分析 

分 类 号：R714.25[医药卫生—妇产科学]