选择性头部亚低温治疗生后6～12h新生儿缺氧缺血性脑病效果  

EFFECT OF SELECTIVE HEAD MILD HYPOTHERMIA TREATMENT ON NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY DURING 6-12 HOURS AFTER BIRTH

作　　者：雷霞[1] 刘崇海[1] 杨霞[1] 

机构地区：[1]川北医学院附属医院新生儿科,南充637000

出　　处：《现代预防医学》2011年第21期4385-4386,4388,共3页Modern Preventive Medicine

摘　　要：[目的]探讨选择性头部亚低温治疗生后6-12h新生儿缺氧缺血性脑病的效果。[方法]将62例生后12h内确诊为缺氧缺血性脑病足月新生儿,随机分为亚低温治疗组（亚低温组32例）和对照组（30例）,亚低温组病儿在生后6-12h内给予选择性头部亚低温治疗,维持肛温在34℃-35℃,持续72h,对照组在常规对症支持治疗下维持肛温在36.7℃-37.5℃。通过观察18个月时的病死率或严重伤残发生率和神经发育评估,评价生后6-12h开始进行亚低温治疗新生儿缺氧缺血性脑病的效果。[结果]18个月时亚低温组的神经发育评分高于对照组,两组相比差异有统计学意义（t=2.949,P﹤0.05）。亚低温组严重不良预后低于对照组,两组比较差异有统计学意义（χ2=4.089,P﹤0.05）。亚低温组病死率和严重神经发育伤残与对照组比较差异无统计学意义（P﹥0.05）。[结论]生后6-12h以内,选择性头部亚低温治疗对新生儿HIE可促进运动发育水平的恢复,降低患儿严重不良预后。[Objective]To study the effect of selective head mild hypothermia（SHMH）on newborn hypoxic ischemic encephalopathy（HIE）during 6-12 hours after birth.[Methods]62 full-term infants with HIE within 12 hours after birth were divided at random into two groups：the treatment group（32 cases）and the control group（30 cases）.The treatment group was treated by SHMH for 72 hours during 6-12 hours after birth.Case fatality rate or serious disability,and neural development diagnosis at 18 month were determined to evaluate the effect s of SHMH during 6-12 hours after birth neonatal HIE.[Results]Compared to the control group,neural development diagnosis of treatment group at 18 month was higher,rate of serious adverse outcomes was lower（P﹤0.05）.Case fatality rate and serious disability of neural development were not different with controls.[Conclusion]The treatment of HIE with SHMH during 6-12 hours after birth is effective,with the function of nervous protection.

关 键 词：生后6~12h 缺氧缺血 亚低温 

分 类 号：R722.1[医药卫生—儿科]