氨氯地平联合贝那普利治疗老年单纯收缩期高血压的临床研究  

CLINICAL STUDY ON AMLODIPINE COMBINED BENAZEPRIL TREATMENT IN OLDER PATIENTS WITH TED SYSTOLIC HYPERTENSION

作　　者：梅少平[1] 姜爱卿[1] 刘芝军[1] 

机构地区：[1]山东省青岛大学医学院附属医院,青岛266003

出　　处：《现代预防医学》2011年第21期4526-4527,共2页Modern Preventive Medicine

摘　　要：[目的]探讨氨氯地平联合贝那普利治疗老年单纯收缩期高血压的临床疗效。[方法]选择2009年5月～2010年5月期间某院收治的老年单纯收缩期高血压患者92例,随机将患者分为研究组和对照组,每组46例。两组患者均给予盐酸贝那普利,而研究组患者则在此基础上加用苯磺酸氨氯地平,并对两组患者的血压变化情况和临床治疗效果进行比较分析。[结果]研究组与对照组相比,其患者的显效率和总有效率均明显提高,分别高达56.52%和95.65%;而无效率则明显降低,仅为4.35%,差异均具有统计学意义(P﹤0.05);同时,其患者的SBP(收缩压)和PP(脉压)均明显降低,差别均具有统计学意义(P﹤0.05)。[结论]氨氯地平联合贝那普利治疗老年单纯收缩期高血压,其疗效确切效果显著,是老年单纯收缩期高血压患者较为理想的联合用药方案。[Objective]To probe into the clinical effects of amlodipine combined benazepril treatment in older patients with isolated systolic hypertension.[Methods]Chose 92 cases with isolated systolic hypertension from May 2009-May 2010 period in our hospital,they were randomly divided into study group and control group,46 cases in each group.Two groups of patients were treated with benazepril hydrochloride,based on that,while patients in this study were used the amlodipine besylate,and blood pressure changes and clinical outcomes of patients in two groups were compared.[Results]Compared with the control group,the significant efficiency and total effective rate of patients in the study group were significantly increased,as high as 56.52% and 95.65%;no efficiency was significantly lower,only 4.35%,there were significant differences（P﹤0.05）.At the same time,SBP（systolic blood pressure）and PP（pulse pressure）of patients in the study group were significantly lower,there were also significant differences（P﹤0.05）.[Conclusion]The curative effect of amlodipine combined benazepril isolated systolic hypertension achieves significant results,which is the ideal combination regimen for patients with isolated systolic hypertension.

关 键 词：单纯收缩期高血压 氨氯地平 贝那普利 老年 

分 类 号：R972.4[医药卫生—药品]