糖皮质激素在创伤致急性呼吸窘迫综合征患者救治中的临床价值  

THE CLINICAL VALUE OF GLUCOCORTICOID IN PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME CAUSED BY TRAUMA

作　　者：戴海涛[1] 乔晓禹[1] 

机构地区：[1]中山大学附属第三医院急诊科,广州510630

出　　处：《现代预防医学》2011年第21期4532-4533,4535,共3页Modern Preventive Medicine

摘　　要：[目的]探讨糖皮质激素在创伤致急性呼吸窘迫综合征患者救治中的临床效果。[方法]选取2007年1月～2011年6月于某院进行治疗的42例创伤致急性呼吸窘迫综合征患者为研究对象,将其随机分为对照组(常规治疗组)21例和观察组(加用糖皮质激素组)21例,后将两组患者的死亡率、机械通气时间、住院时间及治疗前后的氧合指数、尿量、APACHEⅡ评分、血清NO、ET-1、IL-1β、IL-6、CRP、TNF-α水平进行统计及比较。[结果]观察组的死亡率低于对照组,机械通气时间、住院时间均短于对照组,氧合指数高于对照组,尿量大于对照组,APACHEⅡ评分低于对照组,血清NO、ET-1、IL-1β、IL-6、CRP、TNF-α水平均低于对照组,P均﹤0.05,差异均有统计学意义。[结论]糖皮质激素在创伤致急性呼吸窘迫综合征患者救治中的临床效果好,可显著改善预后。[Objective]To study the clinical effect of glucocorticoid in patients with acute respiratory distress syndrome（ARDS）caused by trauma.[Methods]42 patients with acute respiratory distress syndrome caused by trauma in our hospital from January 2007 to June 2011 were selected as research subjects,and they were randomly divided into control group（routine treatment group）21 cases and observation group（glucocorticoid group）21 cases,then the mortality rate,mechanical ventilation time,hospitalization time and oxygenation index,urine volume,APACHEⅡ score and serum NO,ET-1,IL-1β,IL-6,CRP,TNF-α before and after the treatment of two groups were analyzed and compared.[Results]The mortality rate was lower than that of control group,mechanical ventilation time,hospitalization time were both shorter than those of control group,oxygenation index was higher than that of control group,urine volume was more than that of control group,APACHEⅡ score was lower than that of control group,serum NO,ET-1,IL-1β,IL-6,CRP,TNF-α were all lower than those of control group,all P﹤0.05,there were all significant differences.[Conclusion]The clinical effect of glucocorticoid in patients with acute respiratory distress syndrome caused by trauma is better,and it can significantly improve prognosis.

关 键 词：糖皮质激素 创伤 急性呼吸窘迫综合征 临床效果 

分 类 号：R977.1[医药卫生—药品]