新型含噻唑和吡唑环的醛腙类化合物的合成  

Synthesis of Novel Carboxaldehyde Hydrazone Derivatives Containing Thiazole and Pyrazole Ring

作　　者：吕警[1] 王吉德[1] 解正峰[1] 

机构地区：[1]新疆大学化学化工学院,新疆乌鲁木齐830046

出　　处：《合成化学》2011年第6期754-758,808,共6页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20562011;20862015)

摘　　要：1-苯基-3-甲基-吡唑-4-甲醛与氨基硫脲缩合制得醛缩氨基硫脲(Ⅱf～Ⅱh);Ⅱ与α-溴代芳基乙酮反应合成了15个新型的含噻唑和吡唑环的醛腙类化合物(2a～4e),其结构经1H NMR,IR和元素分析表征。X-射线单晶衍射测试结果表明,2c属斜方晶系,空间群Pbca,晶胞参数a=18.607 9(3),b=15.497 7(3),c=27.448 0(5),α=90.00°,β=90.00°,γ=90.00°,Mr=472.79,V=7.915 4(2)nm3,Z=8,Dc=1.587 g.cm-3,F(000)=3 808。Fifteen novel carboxaldehyde hydrazone derivatives（2a～4e） containing thiazole and pyrazole ring were synthesized by condensation reaction of 1-phenyl-3-methyl-pyrazol-4-carboxaldehyde with thiosemicarbazide,then cyclization with α-bromoacetophenone.Their structures were characterized by 1H NMR,IR and elemental analysis.The result of crystal X-ray diffraction showed that 2c belongs to orthorhombic,space group Pbca with a=18.607 9（3）,b=15.497 7（3）,c=27.448 0（5） ,α=90.00°,β=90.00°,γ=90.00°,Mr=472.79,V=7.915 4（2） nm3,Z=8,Dc=1.58 7 g·cm-3,F（000）=3 808.

关 键 词：噻唑 吡唑 醛腙 合成 

分 类 号：O641.4[理学—物理化学]