O,O-双十二酰化-三甲基壳聚糖季铵盐/胆固醇混合单分子膜性质  

Study on mixed monolayers of O,O-dilauryl-N,N,N-trimethyl chitosan quaternary ammonium with cholesterol

作　　者：詹光耀[1] 李明春[1] 辛梅华[1] 关品燊[1] 

机构地区：[1]华侨大学材料科学与工程学院,环境友好功能材料教育部工程中心,福建厦门361021

出　　处：《化工进展》2011年第11期2486-2490,共5页Chemical Industry and Engineering Progress

基　　金：福建省重点科技项目(2009H0030);福建省自然科学基金(2009J01029和2011J01312);科技部科技人员服务企业项目

摘　　要：制备了O,O-双十二酰化-N,N,N-三甲基壳聚糖季铵盐(DATMC),用FTIR、EA和1H NMR对产物进行表征,并研究其与胆固醇(CH)的混合单分子膜性质。结果表明:DATMC在氯仿、THF和DMF中具有良好的溶解性。随着胆固醇含量的增加,DATMC/CH混合分子膜的崩溃压和极限分子占据面积均减小;在任何膜压下,体系的超额自由能ΔGexc<0,说明DATMC与CH二者处于混溶状态。并且XCH=0.8时,ΔGexc最小,此时相容性最好,体系最稳定。实验结果表明,调整胆固醇的含量可以改变混合单分子膜的性质。O,O-Dilauryl-N,N,N-trimethyl chitosan quaternary ammonium（DATMC）was prepared and characterized by FTIR,EA and 1H NMR.The behaviors of mixed monolayers of DATMC and cholesterol（CH）were studied.The experimental results of monolayers properties show that the collapse pressure（πc）and the limiting molecular area（Aex）of mixed monolayers decrease with the increasing of cholestrol content.The results of compatibility indicate that the mixed system is stable as the values of excess molecular area（ΔGexc）are less than zero at any πc,and the most stable state of it is observed when molar concentration of cholestol is 0.8.The experimental results show that the properity of DATMC monolayers changes with the content of cholestrol.

关 键 词：壳聚糖 三甲基化 酰化 胆固醇 单分子膜 

分 类 号：O636.1[理学—高分子化学]