葡萄糖二酸的生物炼制及应用研究进展  

Research progress in preparation and application of bio-refined D-glucaric acid

作　　者：余作龙[1] 苗江月[1] 曹飞[1] 周佳栋[1] 朱璇[1] 王月霞[1] 韦萍[1] 

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京210009

出　　处：《化工进展》2011年第11期2502-2508,2535,共8页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金项目(21106063;30600009)

摘　　要：葡萄糖二酸是含有多羟基的二元酸,广泛来源于葡萄糖基物质,可用于可降解聚合物、药物和食品等产品的制备。本文介绍了硝酸氧化、TEMPO氧化等化学法和生物法制备葡萄糖二酸的原理和方法,并综述了其在抗癌及显像剂药物、聚合物等方面的应用。D-glucaric acid is a dicarboxylic acid containing polyhydroxy.It can be obtained from many glucose-based substances and be used to prepare products of biodegradable polymers,pharmaceuticals and food.In this review,we try to describe the principles and preparation methods of D-glucaric acid in both chemical（nitric acid oxidation and TEMPO oxidation）and biological fields,and review its applications in both pharmaceuticals（anticancer drugs and imaging agents）and polymers.

关 键 词：葡萄糖二酸 葡萄糖 制备 应用 

分 类 号：TQ031[化学工程] TQ073.2