介孔硅纳米储存器在智能药物释放系统的应用  

Application of Mesoporous Silica Nanoreservoir in Smart Drug Controlled Release Systems

作　　者：罗忠[1] 蔡开勇[1] 张蓓璐[1] 段霖[1] 刘艾萍[1] 龚端[1] 

机构地区：[1]重庆大学生物工程学院生物流变科学与技术教育部重点实验室,重庆400044

出　　处：《化学进展》2011年第11期2326-2338,共13页Progress in Chemistry

基　　金：中央高校基本科研业务科研专项重大项目项目(No.CDJZR10238801)资助

摘　　要：开发新型细胞微环境刺激响应性智能药物控释系统是目前材料学、药理学与临床医学研究的共同热点之一,其目的在于寻求合适的药物载体,提高药物的安全性、有效性及降低药物毒副作用。本文综述了介孔硅功能复合纳米材料在生物医药领域的应用研究进展;通过对其进行特定的化学修饰、生物修饰、物理修饰,不仅能特异性细胞识别靶向,还能针对病变细胞实现药物定点、定时、定量的"生物爆破"释放;这在药物可控释放、靶向癌症治疗、靶向基因递送等领域展示了其广阔的应用前景。同时,本文还系统地分析和总结了各种智能响应性介孔硅纳米储存器的制备方法和响应机制,包括"无机纳米塞-介孔硅"纳米智能控释系统、"有机大分子控制器-介孔硅"智能功能复合型控释系统、"分子开关控制器-介孔硅"自响应性纳米控释系统等,这为设计新型响应性介孔硅纳米储存器系统提供了借鉴与思路。To develop novel cell microenvironment stimuli responsive smart controlled-release delivery systems is one of the current common interests of material science,pharmacology and clinical medicine.It＇s purpose includes to look for proper drug carriers,to enhance the safety and availability of drugs,and to reduce the side effect of drugs＇ toxicity.The article reviewed the research development of functional mesoporous silica nanoparticles（MSNs） composites for applications in the field of biomedicine.MSNs composites could be modified via specific chemical reactions,biological methods and physical approaches,to achieve not only targeting based on cell-specific recognition,but also site pointed,timed and quantitatively controlled drug release to malignant cells via a ＂biological explosion＂ approach.It presents wide potential applications in the fields of controlled drug release,targeted cancer therapy and targeted gene delivery.Meanwhile,this article systematically analyzed and summarized various methods for the fabrication of different smart mesoporous silica nanoreservoir and their mechanisms for smart controlled drug release,including inorganic nanoparticles sealed MSNs smart controlled release system,organic molecules sealed MSNs smart controlled release system,self-responsive novel molecular switch based on MSNs controlled release system,which affords references and ideas for designing novel stimuli responsive nanoreservoir system based on MSNs.

关 键 词：介孔硅纳米颗粒 刺激响应性 表面功能化 药物控制释放系统 

分 类 号：O627.41[理学—有机化学] O647.11[理学—化学]