无溶剂条件下有效合成2,3-二氢-4(1H)-喹唑啉酮衍生物  

An efficient synthesis of 2,3-dihydro-4(1H)-quinazolinone derivatives under solvent-free condition

作　　者：许碧晖[1] 夏盛[1] 荣良策[1] 

机构地区：[1]徐州师范大学化学化工学院,江苏徐州221116

出　　处：《徐州师范大学学报（自然科学版）》2011年第3期62-65,共4页Journal of Xuzhou Normal University(Natural Science Edition)

基　　金：江苏省高校自然科学基金资助项目(08KJB150017)

摘　　要：以靛红酸酐、芳醛和芳胺为原料,氢氧化钠为催化剂,在无溶剂条件下加热反应,有效地合成2,3-二氢-4(1 H)-喹唑啉酮衍生物.研究表明,芳醛的环上无论是吸电子基(如卤原子),还是给电子基(如甲基或甲氧基),对反应都没有明显的影响,产物的产率较高,在81%～93%之间.与已有的合成方法相比,本方法具有反应时间短、条件温和、处理简单和环境友好等优点.An efficient method for the preparation of 2,3-dihydro-4（1H）-quinazolinone derivatives by the one-pot reaction of isatiocanhydride,aromatic aldehydes,aromatic amine,in the presence of sodium hydroxide under solvent-free condition is reported.In this study,it is found that,neither bearing electron-withdrawing groups（such as halide） nor electron-donating groups（such as methyl group and methoxyl group） at the rings of aromatic aldehydes have significant effect on this reaction,and the products were gained with high yields（about 81%～93%）.This method has the advantages of excellent yields,mild reaction conditions,easy work-up,and environmentally friendly procedure.

关 键 词：4(1H)-喹唑啉酮 靛红酸酐 无溶剂合成 绿色化学 

分 类 号：O621.3[理学—有机化学]