肾素-血管紧张素系统在糖尿病视网膜病变中的研究进展  

Research progress of renin-angiotensin system in diabetic retinopathy

作　　者：卢欣阳[1] 陈晓隆[1] 

机构地区：[1]中国医科大学附属盛京医院眼科,中国辽宁省沈阳市110001

出　　处：《国际眼科杂志》2011年第11期1941-1944,共4页International Eye Science

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病严重的微血管并发症之一,是目前发达国家成人致盲的主要原因。随着社会的进步和人民生活水平的提高,糖尿病的发病率日趋增多,已经成为危害人类健康的一种严重的侵犯全身多个系统的代谢病,其所引起的眼部并发症成为目前世界上主要的致盲眼病之一。因此,研究DR的发病机制,探讨其治疗途径,是当前眼科领域攻关的重要课题。最新的研究表明,眼部组织具有独立合成肾素-血管紧张素系统(rennin-angiotensin system,RAS)的能力,而且RAS参与了DR的发生发展,阻断RAS对于阻止和治疗DR可能具有重要价值。Diabetic retinopathy（DR） is a microvascular complication of diabetes,and the main reason for adult blindness in developed countries.Along with social progress and people＇s living standards improving,the incidence of diabetes is increasing.And it has become a hazard to human health,a serious violation of multiple body systems and metabolic diseases.The ocular complications caused by it has become one of the world＇s major blinding eye diseases.Therefore,the study of DR in the pathogenesis and its therapeutic approach is currently an important issue in the field of ophthalmology research.The latest research shows that eye tissues are with independent synthetic renin-angiotensin system（RAS） capabilities,but also RAS participates in the occurrence and development of DR,so preventing and blocking the RAS may have important therapeutic value of DR.

关 键 词：糖尿病视网膜病变 发病机制 肾素-血管紧张素系统 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]