比较曲马朵与芬太尼在脊柱手术后自控镇痛的效果与安全性  

Comparision of the efficacy and safety of tramadol with fentanyl in patient-controlled intravenous analgesia after spinal surgery

作　　者：李斌本[1] 陈辉[1] 许华[1] 

机构地区：[1]上海第二军医大学第一附属长海医院麻醉科,200433

出　　处：《实用疼痛学杂志》2011年第4期271-273,共3页Pain Clinic Journal

摘　　要：目的 比较曲马朵与芬太尼在成人脊柱手术后自控镇痛中的效果与安全性.方法 对入选病例随机分为曲马朵T组（60例）和芬太尼F组（60例）,T组采用曲马朵20 mg/kg,F组采用芬太尼20 μg/kg,两组均含氟哌利多1.25 mg,加生理盐水至100 ml,试验采用双盲法.结果 两组患者术后1 hNRS评分、术后呼吸抑制与过度镇静有统计学差异,其余时间段NRS无统计学差异（P〈0.05）.结论 曲马朵在成人脊柱手术后静脉自控镇痛的效果与芬太尼相当,效果确切,但副作用明显少.Objective To compare the efficacy and safety of tramadol with fentanyl in postoperative patient-controlled intravenous analgesia after the adult spinal surgery. Methods The patients were randomly divided into tramadol group T （60 cases） and fentanyl group F （60 cases）. The patients in group T were treated with tramadol 20 mg/kg and in group F with fentanyl 20 /μg/kg. Droperidol 1.25 mg was combined in both groups, then diluted with normal saline to 100 ml. Results Postoperative NRS, respiratory depression and excessive sedation were significantly different between the two groups （P〈0.05） at 1 h after the operation. There was no significant difference of the NRS during the other time. Conclusion The efficacy of tramadol postoperative analgesia after spinal surgery in adults is comparable to that of fentanyl, the analgesic effect is exactly, but the side effects is less.

关 键 词：曲马朵 脊柱 疼痛 手术后 镇痛 患者控制 成年人 

分 类 号：R614[医药卫生—麻醉学]