糖尿病肾病患者血清AT1受体和β1受体自身抗体与血清半胱氨酸蛋白酶抑素C的关系  

Relationship of positive rate of 131-adrenergic and AT1 receptor autoantibodies with serum cystatin C concentration in the patients with diabetic nephropathy

作　　者：赵林双[1] 向光大[1] 浦金辉[1] 侯洁[1] 乐岭[1] 孙慧伶[1] 谭学莹[1] 廖玉华[2] 王敏[2] 

机构地区：[1]广州军区武汉总医院内分泌科,湖北430070 [2]华中科技大学同济医学院协和医院心内科

出　　处：《中华内分泌代谢杂志》2011年第10期833-835,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：湖北省自然科学基金项目（2002AB116）

摘　　要：观察371例糖尿病肾病患者、107例2型糖尿病患者和47名对照者血清β1肾上腺素能（B1）和血管紧张素Ⅱ1型（AT1）受体自身抗体阳性率与血清半胱氨酸蛋白酶抑素c（Cys—C）的关系。结果显示糖尿病肾病患者B1和AT1受体自身抗体阳性率明显高于2型糖尿病患者，糖尿病肾病患者中Cys—c异常者B1和AT1受体抗体阳性率明显高于Cys-C正常者。提示Cys—C异常与肾损害有关，更进一步表明糖尿病肾病与AT1和B1受体自身抗体有关。To observe the relationship between positive rate of β1-adrenergic and AT1 receptors autoantibodies with serum concentration of cystatin C in 371 patients with diabetic nephropathy patients, 107 patients with type 2 diabetes, and 47 subjects as healthy control. In patients with diabetic nephropathy, the positive rates of the β1 and AT1 receptors autoantibodies were significantly higher than those in patients with type 2 diabetes and normal controls. The titers of β1 and AT1 receptors autoantibodies in diabetic nephropathy patients with abnormal cystatin C were significantly higher than those with normal cystatin C concentration. These findings suggested that β1 and AT1 receptors autoantibodie may play important roles in the pathogenesis of diabetic neDhroDathv.

关 键 词：糖尿病肾病 受体 血管紧张素Ⅱ1型 受体 肾上腺素能[51 自身抗体 半胱氨酸蛋白酶 抑素C 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]