糖尿病肾病患者血清AT1受体和β1受体自身抗体与血清半胱氨酸蛋白酶抑素C的关系  被引量:6

Relationship of positive rate of 131-adrenergic and AT1 receptor autoantibodies with serum cystatin C concentration in the patients with diabetic nephropathy

在线阅读下载全文

作  者:赵林双[1] 向光大[1] 浦金辉[1] 侯洁[1] 乐岭[1] 孙慧伶[1] 谭学莹[1] 廖玉华[2] 王敏[2] 

机构地区:[1]广州军区武汉总医院内分泌科,湖北430070 [2]华中科技大学同济医学院协和医院心内科

出  处:《中华内分泌代谢杂志》2011年第10期833-835,共3页Chinese Journal of Endocrinology and Metabolism

基  金:湖北省自然科学基金项目(2002AB116)

摘  要:观察371例糖尿病肾病患者、107例2型糖尿病患者和47名对照者血清β1肾上腺素能(B1)和血管紧张素Ⅱ1型(AT1)受体自身抗体阳性率与血清半胱氨酸蛋白酶抑素c(Cys—C)的关系。结果显示糖尿病肾病患者B1和AT1受体自身抗体阳性率明显高于2型糖尿病患者,糖尿病肾病患者中Cys—c异常者B1和AT1受体抗体阳性率明显高于Cys-C正常者。提示Cys—C异常与肾损害有关,更进一步表明糖尿病肾病与AT1和B1受体自身抗体有关。To observe the relationship between positive rate of β1-adrenergic and AT1 receptors autoantibodies with serum concentration of cystatin C in 371 patients with diabetic nephropathy patients, 107 patients with type 2 diabetes, and 47 subjects as healthy control. In patients with diabetic nephropathy, the positive rates of the β1 and AT1 receptors autoantibodies were significantly higher than those in patients with type 2 diabetes and normal controls. The titers of β1 and AT1 receptors autoantibodies in diabetic nephropathy patients with abnormal cystatin C were significantly higher than those with normal cystatin C concentration. These findings suggested that β1 and AT1 receptors autoantibodie may play important roles in the pathogenesis of diabetic neDhroDathv.

关 键 词:糖尿病肾病 受体 血管紧张素Ⅱ1型 受体 肾上腺素能[51 自身抗体 半胱氨酸蛋白酶 抑素C 

分 类 号:R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象