鸡胚早期发育过程中细胞迁移的基因调控  

Gene Regulation of Cell Migration During the Development of Early Chick Embryo

作　　者：王广[1] 李艳[1] 杨雪松[1] 

机构地区：[1]暨南大学医学院组织与胚胎教研室再生医学教育部重点实验室,广州510632

出　　处：《中国细胞生物学学报》2011年第10期1069-1077,共9页Chinese Journal of Cell Biology

基　　金：国家重点基础研究发展计划(No.2010CB529702);国家自然科学基金(No.30971493;No.31071054)资助项目~~

摘　　要：鸡胚是发育生物学研究的经典动物模型,通过基因导入技术调节胚胎发育的基因功能,研究鸡胚早期发育过程中的细胞迁移,有助于更好地诠释相关先天性疾病的发生发展过程。在早期胚胎发育的过程中,原肠胚期三胚层的形成、心管的发生及神经嵴的发育都伴随着显著的细胞迁移过程。该文将结合近年来国内外对该过程的研究进展,介绍这三个不同时期细胞的迁移及相关基因调控。We employ the chick embryo, a classically embryological model for studying oevelopmental events, to investigate cell migration modulated by early expressing genes in embryogenesis by transgenesis during the development of early chick embryo. This research eventually leads to understanding the fundamental questions in developmental biology and to describing the development of some correlative congenital diseases as well. Cell migration dramatically occurs during the three germ layers formation at gastrula, generation of straight heart tube and delamination of neural crest after neural tube closure. In this review, we will discuss the current research progresses of the cell migration regulated by relevant genes in the three portions mentioned above at cellular and molecular levels.

关 键 词：细胞迁移 基因调控 原条 心管 神经嵴 

分 类 号：S831[农业科学—畜牧学] Q75[农业科学—畜牧兽医]