干细胞多能性信号调控机制研究进展  

Signaling Pathways Regulating the Pluripotency of Pluripotent Stem Cells

作　　者：王娟[1] 孔庆然[1] 王加强[1] 刘忠华[1] 

机构地区：[1]东北农业大学胚胎工程实验室,哈尔滨150030

出　　处：《中国细胞生物学学报》2011年第10期1137-1145,共9页Chinese Journal of Cell Biology

基　　金："973计划"重大科学研究项目(No.2009CB941002;No.932004);黑龙江省杰出青年基金(No.JC200905)资助项目~~

摘　　要：多能性干细胞是一类具有体外无限自我复制和分化为体内多种细胞类型能力的多潜能细胞,是研究基因功能、建立疾病模型和促进再生医学领域发展的一种重要工具。自1981年小鼠胚胎干细胞建立以来,科学家们已经先后成功地建立了灵长类、人、大鼠的胚胎干细胞和小鼠、大鼠的上胚层干细胞等。但是,目前研究表明,维持人、灵长类胚胎干细胞的多能性信号通路与维持小鼠、大鼠胚胎干细胞的截然不同,而与维持小鼠、大鼠上胚层干细胞的信号通路比较类似。因此,该文对目前研究较多的维持小鼠胚胎干细胞、人胚胎干细胞和小鼠上胚层干细胞的多能性信号通路进行了综述,希望能够对其它物种的多能性干细胞研究提供有益的借鉴。Embryonic stem cells can go indefinite self-renewal and give rise to many kinds of cells of the adult body. The derivation of pluripotent stem cells is seminal technological breakthroughs as it provides powerful tools for gene function research, disease models establishment and regenerative medicine. Now primate, human, rat embryonic stem cells and mouse, rat epiblast stem cells have been derived since the first establishment of mouse embryonic stem cells in 1981. However, the signaling pathways regulating the pluripotency in primate and human embryonic stem cells are different from that in mouse and rat embryonic stem cells, but they are similar with that in mouse and rat epiblast stem cells. Understanding the signaling pathways will guide us to use pluripotent stem cells in therapy, and pave the way to establish naive embryonic stem cells widely. This review focuses on the signaling pathways regulating mouse embryonic stem cells （ruES）, human embryonic stem cells （hES） and mouse epiblast stem cells （EpiSC）.

关 键 词：胚胎干细胞 上胚层干细胞 多能性 信号通路 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]